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6 research outcomes, page 1 of 1
  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Karoline B. Kuchenbaecker; Andy R Ness; Graham G. Giles; Graham G. Giles; Nadine Tung; Thilo Dörk; Paul A. James; Hoda Anton-Culver; Emily White; Emily White; ...
    Project: NIH | AUSTRALASIAN C0L0RECTAL C... (3U01CA074778-04S1), NIH | International Partnership... (1D43TW009112-01A1), NHMRC | Australian Prostate Cance... (614296), NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1), NHMRC | Markers of androgen actio... (450104), NIH | Automated Storage and Ret... (1S10RR025141-01), NIH | The Mitochondrial Genome ... (5R01CA149429-05), NIH | The Progesterone Receptor... (1R03CA113148-01), NIH | Unraveling Genetic Determ... (5K07CA172294-06), NIH | Tissue and Pathology Reso... (1P50CA127003-01),...

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of Europ...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Arkaitz Carracedo; Arkaitz Carracedo; Leire Arreal; Ana M. Aransay; Oscar M. Rueda; Nina Radosevic-Robin; José Baselga; Amaia Zabala-Letona; James D. Sutherland; Pilar Sanchez-Mosquera; ...
    Publisher: Nature Publishing Group
    Project: EC | CANCERMETAB (336343), NIH | MOUSE GENETICS (2P30CA008748-43)

    Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggress...

  • publication . Article . 2020
    Open Access English
    Authors:
    Alexandra Leary; Elizabeth M. Swisher; Jonathan A. Ledermann; David Cella; Juliette Meunier; Terri Cameron; Robert W. Holloway; Domenica Lorusso; Giovanni Scambia; Jeffrey C. Goh; ...
    Publisher: American Society of Clinical Oncology
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:sec><jats:title>PURPOSE</jats:title><jats:p> To investigate quality-adjusted progression-free survival (QA-PFS) and quality-adjusted time without symptoms or toxicity (Q-TWiST) in a post hoc exploratory analysis of the phase III ARIEL3 study of rucaparib maintenan...

  • publication . Article . Conference object . 2018
    Open Access
    Authors:
    Hans Lilja; Hans Lilja; Lynn Greenhalgh; Gad Rennert; Kate Richardson; Kate Richardson; Alison Falconer; Eitan Friedman; Eitan Friedman; Wendy A. G. van Zelst-Stams; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    This research is coordinated by the Institute of Cancer Research, London, UK and is supported by grants from Cancer Research UK (Grant references (C5047/A21332, C5047/A13232 and C5047/A17528) and The Ronald and Rita McAulay Foundation. Mr and Mrs Jack Baker for the stud...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Gopa Iyer; José Baselga; Grace Mann; Feng Xu; Carlos L. Arteaga; Jordi Rodon; Alison M. Schram; James J. Harding; Alshad S. Lalani; Victor Moreno; ...
    Project: NIH | USC COMPREHENSIVE CANCER ... (3P30CA014089-17S1), NIH | ERBB2 TARGETED ANTITUMOR ... (5R01CA080195-04), NIH | Understanding Long Tail D... (5R01CA204749-03), NIH | Cancer Center Support (CO... (3P30CA016672-41S4), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Cancer Chemotherapy Train... (5T32CA009207-29), NIH | Center for Clinical and T... (4UL1TR000371-10), NIH | SPORE in Breast Cancer (3P50CA098131-15S1), NIH | Informatics to enable rou... (5U01CA180964-02)

    Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically uncharacterized. Here...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Francesco Leonardi; Nirit Yarom; Teresa Macarulla; T.R. Jeffrey Evans; Luigi Celio; Maya Kolin; Pascal Artru; Corey Carter; David Malka; H. L. Kindler; ...
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    BACKGROUND: Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose...

6 research outcomes, page 1 of 1