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109 research outcomes, page 1 of 11
  • publication . Article . 2012
    Open Access English
    Authors:
    YOU ZHOU;
    Publisher: Public Library of Science
    Project: AKA | Cytoplasmic sterol sensor... (121457), EC | LIPIDOMICNET (202272)

    Oxysterol-binding protein (OSBP) homologues, ORPs, are implicated in lipid homeostatic control, vesicle transport, and cell signaling. We analyzed here the quantity of ORP mRNAs in human subcutaneous (s.c.) and visceral adipose depots, as well as in the Simpson-Golabi-B...

  • publication . Other literature type . Article . 2012
    Open Access English
    Authors:
    Milacic M; Haw R; Rothfels K; Wu G; Croft D; Henning Hermjakob; D’Eustachio P; Stein L;
    Publisher: Multidisciplinary Digital Publishing Institute
    Project: EC | LIPIDOMICNET (202272), WT , NIH | Reactome: An Open Knowled... (5U41HG003751-07)

    Reactome describes biological pathways as chemical reactions that closely mirror the actual physical interactions that occur in the cell. Recent extensions of our data model accommodate the annotation of cancer and other disease processes. First, we have extended our cl...

  • publication . Article . Review . Other literature type . 2012
    Open Access English
    Authors:
    Rudolf Zechner; Robert Zimmermann; Thomas O. Eichmann; Sepp D. Kohlwein; Guenter Haemmerle; Achim Lass; Frank Madeo;
    Publisher: HAL CCSD
    Project: EC | LIPIDOMICNET (202272)

    International audience; Lipid droplets were long considered to be simple storage structures, but they have recently been shown to be dynamic organelles involved in diverse biological processes, including emerging roles in innate immunity. Various intracellular pathogens...

  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Hicks, Andrew A; Pramstaller, Peter P; Johansson, Asa; Vitart, Veronique; Rudan, Igor; Ugocsai, Peter; Aulchenko, Yurii; Franklin, Christopher S; Liebisch, Gerhard; Erdmann, Jeanette; ...
    Publisher: Public Library of Science
    Project: WT , NWO | Dissecting genetic comple... (2300137747), EC | LIPIDOMICNET (202272)

    Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences. Increasingly, variants within a few of t...

  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Silke Imgrund; Dieter Hartmann; Hany Farwanah; Matthias Eckhardt; Roger Sandhoff; Joachim Degen; Volkmar Gieselmann; Konrad Sandhoff; Klaus Willecke;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: EC | LIPIDOMICNET (202272)

    (Dihydro)ceramide synthase 2 (cers2, formerly called lass2) is the most abundantly expressed member of the ceramide synthase gene family, which includes six isoforms in mice. CERS2 activity has been reported to be specific toward very long fatty acid residues (C22–C24)....

  • publication . Article . 2014
    Open Access English
    Authors:
    Kopf, Thomas; Schaefer, Hans-Ludwig; Troetzmueller, Martin; Koefeler, Harald; Broenstrup, Mark; Konovalova, Tatiana; Schmitz, Gerd;
    Project: EC | LIPIDOMICNET (202272)

    Fenofibrate (FF) lowers plasma triglycerides via PPARα activation. Here, we analyzed lipidomic changes upon FF treatment of fructose fed rats. Three groups with 6 animals each were defined as control, fructose-fed and fructose-fed/FF treated. Male Wistar Unilever Rats w...

  • publication . Article . 2012
    Open Access English
    Authors:
    K. E. Pinnick; M. J. Neville; B. A. Fielding; K. N. Frayn; F. Karpe; L. Hodson;
    Publisher: American Diabetes Association
    Project: WT , EC | LIPIDOMICNET (202272)

    The expansion of lower-body adipose tissue (AT) is paradoxically associated with reduced cardiovascular disease and diabetes risk. We examined whether the beneficial metabolic properties of lower-body AT are related to the production and release of the insulin-sensitizi...

  • publication . Thesis . Article . Other literature type . 2008
    Open Access English
    Authors:
    Wiesner, Philipp; Leidl, Katharina; Boettcher, Alfred; Schmitz, Gerd; Liebisch, Gerhard;
    Project: EC | LIPIDOMICNET (202272)

    Glycerophospholipid and sphingolipid species and their bioactive metabolites are important regulators of lipoprotein and cell function. Aim of the study was to develop a method for lipid species profiling of separated lipoprotein classes. Methods: Human serum lipoprotei...

  • publication . Article . 2013
    Open Access English
    Authors:
    Paul Ramm Sander; Markus Peer; Margot Grandl; Ulrich Bogdahn; Gerd Schmitz; Hans Robert Kalbitzer;
    Publisher: Public Library of Science
    Project: EC | LIPIDOMICNET (202272)

    Oxidized and enzymatically modified low-density lipoproteins (oxLDL and eLDL) play a key role in early stages of atherogenesis. Their uptake by recruited macrophages leads to endolysosomal phospholipidosis or foam cell formation, respectively, each of which is preceded ...

  • publication . Article . 2018
    Open Access
    Authors:
    Wallner, Stefan; Grandl, Margot; Liebisch, Gerhard; Peer, Markus; Orsó, Evelyn; Sigrüner, Alexander; Sobota, Andrzej; Schmitz, Gerd;
    Publisher: Public Library of Science (PLoS)
    Project: EC | LIPIDOMICNET (202272)

    Background Extravasation of macrophages and formation of lipid-laden foam cells are key events in the development and progression of atherosclerosis. The degradation of atherogenic lipoproteins subsequently leads to alterations in cellular lipid metabolism that influenc...

109 research outcomes, page 1 of 11
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