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143 research outcomes, page 2 of 15
  • publication . Article . 2017
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    Background. The transforming growth factor beta 1 (TGF-β1) is one of the most important tissue factors secreted by the development of epithelial tumors. Increased expression of TGF-β1 in lung tumors promotes cancer cells survival enhancing their growth, migration, invas...

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  • publication . Other literature type . Article . 2018
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    Background. Multiple myeloma (MM) is a hematologic malignancy of plasma cells. The microenvironment plays a key role in MM cell survival and drug resistance through release of soluble factors, expression of adhesion molecules and release of exosomes (EXs). The role that...

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  • publication . Article . 2016
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    The main problem in the treatment of many cancers is multidrug resistance due to tumor progression. Using nanosized drug delivery systems allows to overcome the mechanisms of multidrug resistance of cancer, in this case, chemotherapeutic agents can effectively introduce...

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  • publication . Article . 2015
    Open Access
    Publisher: Publishing House ABV Press

    Bone metastasis is one of the most frequent and dangerous complications of malignant tumors. The last years, achievements in the study of bone remodeling mechanisms promoted the search of sensitive and specific criteria reflecting the intensity of osteolysis and osteosy...

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  • Objective: to study the sensitivity of gastrointestinal stromal tumors (GISTs) to the topoisomerases type II inhibitors and ability of imatinib to enhance GISTs sensitivity to the chemotherapeutic drugs indicated above. Subjects and Methods. We studied the sensitivity o...

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  • publication . Article . 2017
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    Currently, treatment and diagnostics of neuroendocrine tumors are associated with a number of problems, including absence of a registry for these diseases. The article considers the main approaches and problems of immunohistochemical diagnostics of neuroendocrine tumors...

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  • publication . Article . 2017
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    Gliomas are the most common brain tumors. It is difficult to detect them at early stages of disease and there is a few available therapies providing significant improvement in survival. Mutations of isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) play significant...

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  • publication . Article . 2020
    Open Access
    Authors:
    A. A. Lushnikova;
    Persistent Identifiers
    Publisher: Publishing House ABV Press

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  • publication . Article . 2017
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    Contrary to the generally accepted opinion about stable DNA as the carrier of hereditary information, in a normal (not just cancer) cell, this molecule is subject to the continuous changes as a result of copying errors (in the course of replication), defects of chromoso...

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  • publication . Article . 2016
    Open Access
    Persistent Identifiers
    Publisher: Publishing House ABV Press

    Wnt cascade is one of the most important signal pathways in the cell, which is required for normal embryonic development, differentiation, maintenance of stem cell phenotype and migration. Mutations in this pathway are associated with tumor growth (especially with colon...

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143 research outcomes, page 2 of 15