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21 research outcomes, page 1 of 3
  • publication . Article . 2021
    Open Access
    Authors:
    I. A. Mazerkina; V. A. Evteev; A. B. Prokofiev; O. V. Muslimova; E. Yu. Demchenkova;
    Persistent Identifiers
    Publisher: SCEEMP

    The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo studies in laboratory...

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  • publication . Article . 2021
    Open Access
    Authors:
    E. V. Melnikova; O. A. Rachinskaya; V. A. Merkulov;
    Persistent Identifiers
    Publisher: SCEEMP

    One of the promising areas in the development of innovative products for the treatment of cancer is the use of oncolytic (native or genetically modified) viruses (OLVs) for selective targeting of tumour cells and their destruction, especially as part of combination ther...

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  • publication . Article . 2021
    Open Access
    Authors:
    A. S. Alekseeva; T. B. Shemeryankina; M. N. Lyakina; M. S. Smirnova; E. P. Fedorova; S. D. Kakhramanova;
    Persistent Identifiers
    Publisher: SCEEMP

    Vitamin A is present in multivitamin products mainly in the form of retinol esters: retinyl acetate, retinyl palmitate, and beta carotene—retinol precursor (dimer) found in plants, which is capable of converting into retinol in liver cells. Retinol is determined in medi...

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  • publication . Article . 2021
    Open Access
    Authors:
    M. O. Komarova;
    Persistent Identifiers
    Publisher: SCEEMP

    Until now, there have been no effective treatments for some ophthalmic diseases that have high social significance. Development of therapeutic approaches to such diseases may be complicated due to challenges in diagnosis and selection of clinical trial endpoints. The ai...

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  • publication . Article . 2021
    Open Access
    Authors:
    D. V. Goryachev;
    Persistent Identifiers
    Publisher: SCEEMP

    The criteria for diagnosis and classification of spondyloarthritides (SpAs) have undergone significant changes over the past 10 years. The emergence of new diagnostic methods and availability of new information on the prognosis of the disease outcome made it possible to...

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  • publication . Article . 2021
    Open Access Russian
    Authors:
    E. S. Petrova; D. V. Goryachev; A. D. Kuznetsova;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The need for development of a clinical trial guidance for medicines for bronchial asthma is brought about by the improvement of requirements for research programmmes for new medicines. The aim of the study was to develop a methodological approach to conducting clinical ...

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  • publication . Article . 2021
    Open Access Russian
    Authors:
    O. V. Evdokimova; A. V. Beketova; M. N. Lyakina;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The relevance of this study stems from the need for alignment of test methods used for identification and assay of anthracene derivatives in herbal preparations and herbal medicinal products. The aim of the study was to analyse Russian and international quality standard...

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  • publication . Article . 2021
    Open Access
    Authors:
    D. P. Romodanovsky; A. L. Khokhlov; D. V. Goryachev;
    Persistent Identifiers
    Publisher: SCEEMP

    The coronavirus (COVID-19) pandemic, which began in 2020, has affected all spheres of life, including clinical trial processes. Health authorities around the world issued recommendations aimed at minimising the risks of virus spreading and ensuring the safety of study p...

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  • publication . Article . 2021
    Open Access
    Authors:
    P. V. Shadrin; T. A. Batuashvili; L. V. Simutenko; N. P. Neugodova;
    Persistent Identifiers
    Publisher: SCEEMP

    The median lethal dose (LD50) and low lethal dose (LD10) are calculated in acute toxicity studies, as well as during specific activity assessment of some medicines. The aim of the study was to develop a procedure for using CombiStats to calculate LD50 and LD10. The auth...

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  • publication . Article . 2021
    Open Access
    Authors:
    N. E. Kuz'mina; S. V. Moiseev; B. K. Romanov;
    Persistent Identifiers
    Publisher: SCEEMP

    Near-infrared spectrometry (NIRS) is a new pharmacopoeial method. It is widely used in the pharmaceutical industry for quality control of medicinal products at various production stages (control of raw materials and finished products), and for detection of substandard a...

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21 research outcomes, page 1 of 3