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101 research outcomes, page 9 of 11
  • publication . Article . 2020
    Open Access Russian
    Authors:
    N. P. Antonova; I. M. Morgunov; S. P. Prokhvatilova; E. P. Shefer; A. M. Kalinin; T. A. Golomazova;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    Specialists in pharmacognosy are facing an important task of improving quality control methods for combination herbal medicinal products in order to enable reliable assessment of the content of active substances that are responsible for the drug’s pharmacological effect...

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  • publication . Article . 2020
    Open Access Russian
    Authors:
    I. A. Mazerkina; V. A. Evteev; A. B. Prokofiev; O. V. Muslimova; E. Yu. Demchenkova;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    Organic anion transporters OAT1 and OAT3 play a key role in elimination of most β-lactam antibiotics. Since nonsteroidal anti-inflammatory drugs, antivirals, antitumor agents, and some other drugs are also substrates of OAT1/3, this enables drug-drug interaction (DDI). ...

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  • publication . Article . 2020
    Open Access
    Authors:
    V. M. Kosman; M. V. Karlina; O. N. Pozharitskaya;
    Persistent Identifiers
    Publisher: SCEEMP

    The HPLC-UV method is widely used for quantitative analysis of drug substances found in biological samples obtained in pharmacokinetics studies, bioequivalence studies, or during therapeutic drug monitoring. The main limitation is associated with a significant backgroun...

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  • publication . Article . 2018
    Open Access Russian
    Authors:
    V. M. Shchukin; E. Yu. Severinova; N. E. Kuz’mina; V. A. Yashkir; V. A. Merkulov;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The article looks into the main problems of determination of iodine trace amounts in multivitamins by inductively coupled plasma-atomic emission spectrometry (ICP-AES), i.e. spectral overlaps attributable to macro-components, and the background effect of organic compoun...

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  • publication . Article . 2021
    Open Access
    Authors:
    V. M. Kosman; N. M. Faustova; M. V. Karlina; V. G. Makarov; M. N. Makarova;
    Persistent Identifiers
    Publisher: SCEEMP

    Abstract. Medicinal products of natural origin are widely used by virtue of their pharmacological efficacy and relative safety. Chemical composition of such medicines is usually complex, they may be represented by heteropolymers or mixtures containing peptides, polysacc...

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  • publication . Article . 2020
    Open Access
    Authors:
    O, A. Bezborodova; A. A. Pankratov; E. R. Nemtsova; Yu. B. Venediktova; M. S. Vorontsova; G. N. Engalycheva; R. D. Syubaev;
    Persistent Identifiers
    Publisher: SCEEMP

    The decoding of the DNA structure and development of new molecular methods of its analysis, as well as identification of specific genomic changes responsible for malignant transformation, have become the turning points in elaboration of novel anti-tumour drugs directed ...

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  • publication . Article . 2020
    Open Access
    Authors:
    L. N. Frolova; E. L. Kovaleva; E. I. Sakanyan; V. Yu. Kuteynikov; V. V. Shelestova; M. A. Cheremisina;
    Persistent Identifiers
    Publisher: SCEEMP

    The study of the nomenclature of officinal herbal substances and medicinal plants is important for finding potential ways of expanding the existing range of raw materials used in the production of herbal medicinal products. The authors compared the standards included in...

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  • publication . Article . 2018
    Open Access
    Authors:
    V. А. Vavilova; E. V. Shekunova; V. A. Kashkin; M. N. Makarova; V. G. Makarov; A. Ya. Khaymenov;
    Persistent Identifiers
    Publisher: SCEEMP

    At present all new medicinal products and cosmetics that absorb medium-wavelength UVB, long-wavelength UVA, or visible light in the range 290–700 nm need to be tested for potential phototoxicity. phototoxicity is evaluated by both in vitro and in vivo methods. There are...

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  • publication . Article . 2021
    Open Access Russian
    Authors:
    N. P. Antonova; E. P. Shefer; N. E. Semenova; S. S. Prokhvatilova; A. M. Kalinin; S. A. Kuchugurin; V. N. Makukhin;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    Abstract. Papaverine hydrochloride products are used as anticonvulsants in routine medical practice. Most of the approved product specification files include thin-layer chromatography for assessment of product-related impurities and UV spectrophotometry for determinatio...

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  • publication . Article . 2020
    Open Access Russian
    Authors:
    D. V. Goryachev; N. E. Uvarova; G. V. Shukshina;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    No new drug can be used in clinical practice without marketing authorisation. Acquisition of the necessary amount of clinical data may take several years, which is especially critical for pernicious diseases for which no alternative therapy is available. Lack of treatme...

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101 research outcomes, page 9 of 11