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55 research outcomes, page 3 of 6
  • publication . Article . 2019
    Open Access Russian
    Authors:
    Goroshko, O. A.; Krasnykh, L. M.; Kukes, V. G.; Zozina, V. I.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled release of reactive ox...

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  • publication . Article . 2018
    Open Access Russian
    Authors:
    Antonova, N. P.; Morgunov, I. M.; Prokhvatilova, S. S.; Shefer, E. P.; Kalinin, A. M.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

     The use of assay methods with different test conditions for determination of anthracene derivatives in herbal substances and herbal medicinal products requires adjustment of the established limits for total anthracene derivatives content based on the test method used.T...

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  • publication . Article . 2018
    Open Access Russian
    Authors:
    Romodanovsk, D. P.; Khokhlov, A. L.; Miroshnikov, A. E.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    Nowadays retrospective analysis of bioequivalence studies of medicinal products that have the same International Nonproprietary Name is becoming particularly relevant. Over the past years we have accumulated a sufficient pool of data in the Russian Federation which make...

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  • publication . Article . 2019
    Open Access Russian
    Authors:
    Ioutsi, A. N.; Sumtsov, M. A.; Artyushenko, D. A.; Bychenkov, D. V.; Blinov, A. N.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The traditional gas-liquid chromatography (GLC) method using packed columns is still used in pharmaceutical analysis for determination of parabens, despite the fact that this technique has a number of serious drawbacks.The aim of the study was to develop a more effectiv...

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  • publication . Article . 2019
    Open Access Russian
    Authors:
    Pisarev, V. V; Ulyashova, Maria M; Gildeeva, Gelia N;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    An integral part of preclinical pharmacokinetic studies is the development of a bioanalytical method for determination of the drug in a biological fluid.The aim of the research was to assess the suitability of the test system based on enzyme-linked immunosorbent assay (...

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  • publication . Article . 2019
    Open Access Russian
    Authors:
    Shevtsov, V. A.; Olefir, Yu. V.; Merkulov, V. A.; Bondarev, V. P.; Indikova, I. N.; Evreinova, E. E.; Rukavishnikov, A. V.; Khantimirova, L. M.; Gorenkov, D. V.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The management of post-approval changes to registration dossiers for medicinal products is one of the most important factors for ensuring sustainable quality, safety and efficacy of medicines. Competent authorities that use the module format of the registration dossier,...

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  • publication . Article . 2019
    Open Access Russian
    Authors:
    Antonova, N. P.; Shefer, E. P.; Kalinin, A. M.; Semenova, N. E.; Prokhvatilova, S. S.; Morgunov, I. M.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The quality control of the «Valerian rhizome and roots» herbal substance is carried out using high performance liquid chromatography (HPLC) according to the State Pharmacopoeia of the Russian Federation, XIV edition. The quantitative analysis of the active ingredients i...

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  • publication . Article . 2021
    Open Access Russian
    Authors:
    E. S. Petrova; D. V. Goryachev; A. D. Kuznetsova;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The need for development of a clinical trial guidance for medicines for bronchial asthma is brought about by the improvement of requirements for research programmmes for new medicines. The aim of the study was to develop a methodological approach to conducting clinical ...

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  • publication . Article . 2018
    Open Access Russian
    Authors:
    E. V. Yakovleva;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The article describes the main stages of introduction of the Good Distribution Practice (GDP) in Russia following the adoption of new laws making it mandatory for wholesalers to comply with requirements for storage and transportation of medicinal products. The article c...

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  • publication . Article . 2018
    Open Access Russian
    Authors:
    Purim, Yu. B.; Kruglyakova, M. L.; Bulanova, L. N.; Agapkina, M. V.; Stronova, L. N.; Bokovikova, T. N.; Gernikova, E. P.;
    Persistent Identifiers
    Publisher: OOO “Vashe Tsifrovoe Izdatelstvo”

    The need for identification testing of active substances or excipients in multi-component medicinal products, including the use of qualitative tests, calls for research substantiating the choice of tests and test conditions with due regard to interference effects caused...

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55 research outcomes, page 3 of 6