In this work, CoCrNi, FeCoCrNi and CoCrFeMnNi concentrated alloys with a Y-Ti oxide particle dispersion were prepared by mechanical alloying and Spark Plasma Sintering. The alloy consists of an FCC Ni-based matrix with a Y-Ti oxide dispersion and additional phases of Cr23C6 and Cr2O3. The effect of Fe, Mn, and Y-Ti oxide particles on the formation of oxide scales and the composition of the adjacent CoCrNi and FeCoCrNi alloys was studied. It was found that alloys without Mn in their composition form a protective Cr2O3 scale. The Cr23C6 particles provide an alternative mechanism for balancing the chromium loss during the oxidation. Y and Ti from the oxide particles participate in the formation of the protective oxide scales. Fe promotes Y and especially Ti diffusion through the Cr2O3 scale, resulting in the formation of Ti-depleted regions in the alloy. The findings will serve for the further development of these new materials.