According to the fifth assessment report of the Intergovernmental Panel on Climate Change, changes in land use through urbanization and agriculture are the key anthropogenic effects of climate change. Thus, the preservation of natural environment of urban areas is essential for conserving water and soil, while still adjusting the microclimatic variables (temperature, precipitation, relative humidity, etc.) and stabilizing the natural ecological system from destruction. It has been observed that most parts of city's green vegetation have been lost due to housing developments and commercial activities. This study was carried out to assess the effect of the change in land use on a modern city like Sunyani, by observing the significant changes in vegetation cover from LANDSAT TM imagery over a 31-year period (1986-2017). From the study, there was significant decline of vegetation cover from 1986 to 1999, and no significant change from 1999 to 2017. There were also significant changes in the built-up areas from 1986 to 1999 and no significant change from 1999 to 2017. Adoption of sustainable and environmentally friendly technologies that maintain open green vegetation is recommended for future city planning.