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  • Open Access English
    Authors: 
    Je Seop Lee; Yong Sung Cha; Seonghoon Yeon; Tae Youn Kim; Yoonsuk Lee; Jin Geul Choi; Kyoung-Chul Cha; Kang Hyun Lee; Hyun Ok Kim;
    Publisher: The Korean Academy of Medical Sciences

    Background It is difficult to diagnose patients with poisoning and determine the causative agent in the emergency room. Usually, the diagnosis of such patients is based on their medical history and physical examination findings. We aimed to confirm clinical diagnoses us...

  • Closed Access
    Authors: 
    Tito R. Mendoza;
    Publisher: Springer International Publishing

    In a previous chapter, how best to measure symptoms was discussed, the desirable properties of a psychometrically valid symptom assessment tool were listed, available symptom assessment tools were reviewed, methods to assist in the interpretation of patient-reported out...

  • Publication . Part of book or chapter of book . 2020
    Closed Access
    Authors: 
    Peng Chen; Timothy R. Billiar;
    Publisher: Springer Singapore

    Multiple organ dysfunction syndrome (MODS), also referred to as external challenge-induced multiple organ injury, is characterized by dysfunction of two or more organs during infection or following shock or trauma. The pathogenesis of MODS is multifactorial and involves...

  • Publication . Article . 2016
    Open Access
    Authors: 
    Giovanna Riolo; Danny Arora; David Taylor; Frcs Gavin Ca Wood MBChB;
    Publisher: Dougmar Publishing Group, Inc.

    We present a unique case of atraumatic rhabdomyolysis and four-limb compartment syndrome. Edema and inflammation associated with rhabdomyolysis, was further exacerbated by aggressive saline resuscitation. This resulted in raised compartment pressures and necessitated fo...

  • Open Access
    Authors: 
    Rajat Gupta; Richie Gupta;
    Publisher: Scientific Scholar

    Objectives: There has been a rapid increase in respiratory infections due to COVID-19, caused by SARS-CoV-2, a novel coronavirus, which is believed to have originated from Wuhan in China. The disease has taken a form of pandemic and is now present in all countries acro...

  • Publication . Part of book or chapter of book . 2020
    Closed Access
    Authors: 
    Nitin Patil; Heike Allgayer; Jörg H. Leupold;
    Publisher: Springer International Publishing

    The tumor microenvironment (TME) is decisive for the eradication or survival of any tumor mass. Moreover, it plays a pivotal role for metastasis and for providing the metastatic niche. The TME offers special physiological conditions and is composed of, for example, surr...

  • Open Access English
    Authors: 
    Hyeon Jeong Suh; Eun Young Lee; Sang Won Park;
    Publisher: The Korean Academy of Medical Sciences

    Background Some coronavirus disease 2019 (COVID-19) patients initially present with early oxygen demand, requiring more medical resources, and some develop severe conditions, while others worsen later in their clinical course. Whether the nature of the two groups is the...

  • Open Access
    Authors: 
    Chunjin Ke; Chong Yu; Daoyuan Yue; Xing Zeng; Zhiquan Hu; Chunguang Yang;
    Publisher: Elsevier BV

    Abstract Background Novel coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. At the peak of the outbreak in Wuhan (January and February), there are two types of COVID-19 patients: laboratory confirmation and clinical diagnosis. T...

  • Closed Access
    Authors: 
    G. Ramírez-Guerrero; Hans Müller-Ortiz; Cristian Pedreros-Rosales;
    Publisher: Elsevier BV

    Resumen La poliuria es una condicion clinica frecuente caracterizada por un volumen de orina inapropiadamente alto para los niveles de presion arterial y sodio plasmatico del paciente (volumen de orina > 3 L/24 h). Desde el punto de vista fisiopatologico se clasifica en...

  • Open Access English
    Authors: 
    Songjun Shao; Haiyan Fang; Lindi Duan; Xianwei Ye; Shanshan Rao; Jin Han; Yumei Li; Guohang Yuan; Weijia Liu; Xiangyan Zhang;
    Publisher: Termedia Publishing House

    Introduction Lysyl hydroxylase 3 (LH3) is a collagen post-translational modifying enzyme; it is abnormally activated during the formation of collagen cross-links. iCRT3 is an inhibitor of both Wnt and β-catenin responsive transcription. We hypothesized that LH3 is regul...

  • Closed Access
    Authors: 
    Stefanie Meißner; Sebastian Nuding; Jochen Schröder; Karl Werdan; Henning Ebelt;
    Publisher: Springer Science and Business Media LLC

    Entsprechend den Empfehlungen des ILCOR (International Liaison Committee on Resuscitation) von 2003 wird die Anwendung der therapeutischen Hypothermie bei bewusstlosen erwachsenen Patienten empfohlen, die einen Kreislaufstillstand unabhangig vom initial registrierten He...

  • Publication . Part of book or chapter of book . 2020
    Closed Access
    Authors: 
    Afsaneh Adibfar; Samaneh Hosseini; Mohamadreza Baghaban Eslaminejad;
    Publisher: Springer International Publishing

    Stimuli-responsive polymers (SRPs) are a recent innovative approach that has numerous biomedical applications. These smart polymers can be used in various industrial and medical areas. Smart polymeric hydrogels are a new class of biomedical materials that have attracted...

  • Closed Access
    Authors: 
    Sam Adie; Ian A. Harris; Alwin Chuan; Peter L. Lewis; Justine M. Naylor;
    Publisher: AMPCo

    The minimum requirements for total knee arthroplasty (TKA) are significant, prolonged symptoms with supporting clinical and radiological signs. Despite interest in screening tools, there is limited evidence for a specific symptom threshold that justifies surgery. Non-op...

  • Open Access English
    Authors: 
    Alvaro Cesar Ruas; Paulo Alves Maia; Rodrigo Cauduro Roscani; Daniel Pires Bitencourt; Fabiano T. Amorim;
    Publisher: Associação Nacional de Medicina do Trabalho (ANAMT)

    Currently, occupational heat exposure is usually measured using environmental variables such as the wet bulb globe temperature index. The costs of heat stress monitoring include the acquisition of specialized equipment and the recruitment of trained personnel. In rapidl...

  • Closed Access
    Authors: 
    Joaquim Torné Cachot; José Manuel Baucells Azcona; Jesús Blanch Falp; Helena Camell Ilari;
    Publisher: Elsevier BV

    Abstract Objectives The aim of this study was to evaluate the characteristics of fever of unknown origin (FUO) according to the definition with qualitative study criterion and of patients without diagnosis. Materials and methods Prospective observational study performed...

  • Closed Access
    Authors: 
    Romina Abelleira; Carlos Zamarrón; Alberto Ruano; Tamara Lourido; Nuria Rodríguez-Núñez; Francisco J. González-Barcala; María E. Toubes; José Manuel Álvarez-Dobaño; Jorge Ricoy; Luis Valdés;
    Publisher: Elsevier BV

    Resumen Introduccion La diabetes mellitus y el sindrome de apnea-hipopnea del sueno parecen estar relacionados, pero no esta bien definido si en los pacientes con ambas enfermedades existe un mayor riesgo de neuropatia periferica. Para ello, realizamos una revision sist...

  • Publication . Part of book or chapter of book . 2019
    Closed Access
    Authors: 
    Magdalena Kostrzon; Agnieszka Sliwka; Tomasz Wloch; Małgorzata Szpunar; Dorota Ankowska; Roman Nowobilski;
    Publisher: Springer International Publishing

    Pulmonary rehabilitation (PR) has been recommended as an integral part of treatment for patients with chronic obstructive pulmonary disease (COPD). Climate therapy in salt mine chambers has been found of benefit in chronic respiratory diseases. The study compares long-t...

  • Closed Access
    Authors: 
    B Koirala; Gerald M. Saidel; A Hernández; L B Gladden; Nicola Lai;
    Publisher: Springer International Publishing

    Insufficient O2 delivery to, and uptake by skeletal muscle can produce mobility limitations for patients with chronic diseases. Near-infrared spectroscopy (NIRS) can be used to noninvasively quantify the balance between skeletal muscle O2 delivery and utilization during...

  • Open Access
    Authors: 
    Dimitrios Patoulias; Aristi Boulmpou; Konstantinos Imprialos; Konstantinos Stavropoulos; Christodoulos Papadopoulos; Michael Doumas;
    Publisher: Elsevier BV

    Resumen Los pacientes con diabetes mellitus tipo 2 (DMT2) presentan un mayor riesgo de experimentar una enfermedad grave por coronavirus 2019 (COVID-19) con un incremento de la mortalidad relacionada. Los agonistas del receptor del peptido similar al glucagon tipo 1 (AR...

  • Open Access
    Authors: 
    Xiaodong Wang; Yong-Bing Xiang; Beili Gao;
    Publisher: Elsevier BV
  • Closed Access
    Authors: 
    Xiangrong Zhou;
    Publisher: Springer International Publishing

    This chapter focuses on modern deep learning techniques that are proposed for automatically recognizing and segmenting multiple organ regions on three-dimensional (3D) computed tomography (CT) images. CT images are widely used to visualize 3D anatomical structures compo...

  • Open Access
    Authors: 
    Rolake Kuye; Catherine S. Riggs; Jordan B. King; Rachel M. F. Heilmann; Deanna Kurz; Jessica L. Milchak;
    Publisher: Annals of Family Medicine

    The purpose of this retrospective matched-cohort study was to evaluate the stability of thyroid stimulating hormone (TSH) in patients using synthetic compared with desiccated thyroid products. Patients using a thyroid product for the treatment of hypothyroidism were mat...

  • Open Access English
    Authors: 
    Hanan M Ibrahim; Mervat Gamal Eldin Mansour; Yasmin G. El Gendy;
    Publisher: Termedia Publishing House

    Introduction Malnutrition affects 50% of hospitalized children and 25–70% of critically ill children. Enteral tube feeding is generally considered the preferred modality for critically ill pediatric patients. Clinical advantages of using peptide-based formulas are still...

  • Closed Access
    Authors: 
    Seon Cheol Park; Yong Ku Kim;
    Publisher: Springer Singapore

    The Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition (DSM-IV) was revised based on a combination of a categorical and a dimensional approach such that in the DSM, Fifth Edition (DSM-5), depressive disorders have been separated as a distinctive diseas...

  • Closed Access
    Authors: 
    Christoph Adler; Stephan Baldus;
    Publisher: Springer Science and Business Media LLC

    The determination of high-sensitivity troponin remains the gold standard in patients with acute chest pain and allows the early diagnosis and therapy of patients with acute myocardial infarction (AMI). Increased cardiac troponin levels are highly specific for myocardial...

  • Publication . Article . 2020
    Closed Access
    Authors: 
    Norbert Reckefuß;
    Publisher: Springer Science and Business Media LLC

    Der Verlauf der kritischen Erkrankung gliedert sich in mehrere Phasen (fruhe und spate Akutphase, Postakutphase), in denen unterschiedliche metabolische Prozesse stattfinden. Entsprechend sollte auch die medizinische Ernahrungstherapie phasengerecht an die metabolische ...

  • Closed Access
    Authors: 
    Chiara Bazzichetto; Fabiana Conciatori; Italia Falcone; Ludovica Ciuffreda;
    Publisher: Springer International Publishing

    The mammalian target of rapamycin (mTOR) represents a critical hub for the regulation of different processes in both normal and tumor cells. Furthermore, it is now well established the role of mTOR in integrating and shaping different environmental paracrine and autocri...

  • Publication . Part of book or chapter of book . 2021
    Closed Access
    Authors: 
    Mrinal K. Das; Taral R. Lunavat; Hrvoje Miletic; Jubayer A Hossain;
    Publisher: Springer International Publishing

    Stem cells play a pivotal role in the developmental stages of an organism and in adulthood as well. Therefore, it is not surprising that stem cells constitute a focus of extensive research. Indeed, several decades of stem cell research have tremendously increased our kn...

  • Closed Access
    Authors: 
    Dário Ligeiro; Martin Rao; Andreia Maia; Mireia Castillo; Antonio Beltran; Markus Maeurer;
    Publisher: Springer International Publishing

    We review state-of-the-art in translational and clinical studies focusing on the tumor microenvironment (TME) with a focus on tumor-infiltrating B cells (TIBs). The TME is a dynamic matrix of mutations, immune-regulatory networks, and distinct cell-to-cell interactions ...

  • Publication . Article . 2016
    Open Access
    Authors: 
    Moshe Gelber; Ina Dubin; Ami Schattner;
    Publisher: Oxford University Press (OUP)

    A 91-year-old patient with dementia was admitted for a recent deterioration and refusal to feed. Examination was non-contributory. The admission chest X-ray showed an unexpected opacity in the …

  • Publication . Part of book or chapter of book . 2020
    Closed Access
    Authors: 
    Christina Nikolakopoulou; Janet A. Willment; Gordon D. Brown;
    Publisher: Springer Singapore

    Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserve...

  • Closed Access
    Authors: 
    David W. Sime;
    Publisher: Springer International Publishing

    Virtual Reality has been used to great effect in the field of retraining and strengthening neural pathways in victims of serious brain injury and stroke.

  • Open Access
    Authors: 
    Fernanda Oliveira Ulguim; Jane Dagmar Pollo Renner; Hildegard Hedwig Pohl; Caio Fernando de Oliveira; Guilherme Cassão Marques Bragança;
    Publisher: EDITORA SCIENTIFIC

    Background Work might cause severe physical stress associated with emotional overload, especially among hospital employees. Objective To identify risk factors for cardiovascular diseases and occupational stress among employees of a teaching hospital. Method Cross-sectio...

  • Closed Access
    Authors: 
    Polyxeni Kaimara; Antonia Plerou; Ioannis Deliyannis;
    Publisher: Springer International Publishing

    Electroencephalography (EEG) systems and brain-computer interfaces (BCIs) are terms frequently involved in the field of neurological research. Under a technological point of view, BCI is considered to be a significant achievement within the frame of learning disabilitie...

  • Publication . Article . 2016
    Open Access
    Authors: 
    Pearce, John M. S.;
    Publisher: Oxford University Press (OUP)

    The earliest known Greek medical school opened in Cnidus in the Hellenistic period BCE. Alcmaeon of Croton, author of the first anatomical text, worked at this school in the 6th and 7th centuries BCE. Before Hippocrates, he suggested that man might be constituted of Tal...

  • Closed Access
    Authors: 
    Jennifer Apolinário-Hagen; Marie Drüge; Severin Hennemann; Bernhard Breil;
    Publisher: Springer Singapore

    Major depressive disorder (MDD) represents a key contributor to the global burden of mental illness given its relatively high lifetime prevalence, frequent comorbidity, and disability rates. Evidence-based treatment options for depression include pharmacotherapy and psy...

  • Publication . Part of book or chapter of book . 2021
    Closed Access
    Authors: 
    Matthias Walter;
    Publisher: Springer International Publishing

    Penile cancer is rare but associated with a high morbidity and mortality once metastasized. Besides presenting a fundamental overview of penile cancer, the current literature on key players associated with the pathogenesis of penile cancer including common labor chemist...

  • Publication . Article . 2021
    Closed Access
    Authors: 
    Terence W.H. Chong; Helen Macpherson; Mia A. Schaumberg; Belinda M. Brown; Sharon L. Naismith; Genevieve Z. Steiner;
    Publisher: AMPCo

    "A multilayered action plan is needed for a substantial, timely and sustained investment in dementia prevention"

  • Publication . Part of book or chapter of book . 2019
    Closed Access
    Authors: 
    Kelly L. Wormwood; Liulin Deng; Ahmed M. Hamid; Daniel DeBord; Laura Maxon;
    Publisher: Springer International Publishing

    The pharmaceutical and clinical industries are imperative for the maintenance of global health and welfare and require accurate, reproducible, and high throughput analyses. Technological advancements, such as the development and implementation of liquid chromatography-t...

  • Publication . Other literature type . Article . 2020
    Open Access
    Authors: 
    Mingliang Dai; Lars E. Peterson;
    Publisher: Annals of Family Medicine

    PURPOSE The purpose of this study was to characterize graduates of family medicine (FM) residencies from 1994 to 2017 and determine whether they continue to practice family medicine after residency. METHOD We sampled physicians who completed FM residency training from 1...

  • Open Access
    Authors: 
    Shyam Ganti; Ravinder Bhanot; Jasleen Kaur; Cassondra Cramer-Bour; Ayman O. Soubani;
    Publisher: Cleveland Clinic Journal of Medicine

    Although routine testing is common, it has low diagnostic yield and is unlikely to alter patient management.

  • Closed Access
    Authors: 
    Stephen Parnis;
    Publisher: Wiley
  • Closed Access
    Authors: 
    Navarro-Tableros, Victor; Gomez, Yonathan; Brizzi, Maria Felice; Camussi, Giovanni;
    Publisher: Springer International Publishing

    Insulin-dependent diabetes mellitus or type 1 diabetes mellitus (T1DM) is an auto-immune condition characterized by the loss of pancreatic β-cells. The curative approach for highly selected patients is the pancreas or the pancreatic islet transplantation. Nevertheless, ...

  • Publication . Part of book or chapter of book . 2020
    Closed Access
    Authors: 
    Jianchao Li; Mingjie Zhang;
    Publisher: Springer International Publishing

    Unconventional myosins are a large superfamily of actin-based molecular motors that use ATP as fuel to generate mechanical motions/forces. The distinct tails in different unconventional myosin subfamilies can recognize various cargoes including proteins and lipids. Thus...

  • Open Access English
    Authors: 
    Francisco Jiménez-Morillas; Manuel Gil-Mosquera; Eric Jorge García-Lamberechts;
    Publisher: Elsevier España, S.L.U.

    The increase in international travel, the growing presence of arbovirus vectors in our country, and notifications of haemorrhagic fever such as the current outbreak of Ebola in D.R. Congo and the cases of Crimea-Congo haemorrhagic fever in our country have again cast th...

  • Closed Access
    Authors: 
    María Esther Guisado-Espartero; Prado Salamanca-Bautista; Óscar Aramburu-Bodas; Luis Manzano; M. Angustias Quesada Simón; Gabriela Ormaechea; Sara Carrascosa García; Marcos García; José María Cepeda Rodrigo; Manuel Montero-Pérez-Barquero; +21 more
    Publisher: Elsevier BV

    Resumen Introduccion Los datos disponibles de las causas de muerte en pacientes ingresados por insuficiencia cardiaca en servicios de medicina interna y en poblacion espanola segun fraccion de eyeccion reducida (FER), preservada (FEP) e intermedia (FEI) son escasos. Su ...

  • Open Access English
    Authors: 
    Yunhye Oh; Yoo Sook Joung; Jung Won Choi;
    Publisher: The Korean Academy of Medical Sciences

    This study's aim was to investigate whether the incidence of neutropenia was higher in subjects who received a combination pharmacotherapy with valproate (VPA), antipsychotics (APs), and attention deficit hyperactivity disorder (ADHD) medication than in those administer...

  • Publication . Article . 2019
    Open Access
    Authors: 
    Keks, Nicholas; Schwartz, Darren; Hope, Judy;
    Publisher: NPS MedicineWise

    In general, specialist advice should be sought when stopping or switching antipsychotics While antipsychotics are often needed long term, there are circumstances when clinicians, patients and families should reconsider the benefits versus the harms of continuing treatme...

  • Open Access English
    Authors: 
    Marieke L A de Hoog; Roderick P Venekamp; Roger A M J Damoiseaux; Anne G M Schilder; Elisabeth A. M. Sanders; Henriette A. Smit; Patricia Bruijning-Verhagen;
    Country: Netherlands

    PURPOSE Annual influenza immunization in medical risk groups is recommended in many countries. Recent evidence suggests that repeated inactivated influenza vaccine (IIV) immunization throughout childhood may impair long-term immunity against influenza. We assessed wheth...

  • Open Access English
    Authors: 
    Sumin Hong; Seolmin Kim; Doo Heum Park; Seungho Ryu; Jee Hyun Ha; Hong Jun Jeon;
    Publisher: The Korean Academy of Medical Sciences

    Background This study aimed to determine if sleep disturbances may mediate the relationship between panic symptoms and depression in patients with panic disorder (PD). Methods Electronic medical records were retrospectively reviewed for 110 consecutive patients with dia...