Advanced search in
Research products
arrow_drop_down
Searching FieldsTerms
Field of Science [Beta]
arrow_drop_down
is
arrow_drop_down
basic medicine
Include:

Filters

2,205,792 Research products, page 1 of 44,116

50
arrow_drop_down
Relevance
arrow_drop_down
  • Open Access English
    Authors: 
    Zhai, Laiyuan; Zheng, Tianqing; Wang, Xinyu; Wang, Yun; Chen, Kai; Wang, Shu; Wang, Yun; Xu, Jianlong; Li, Zhikang;
    Publisher: SpringerOpen

    Background The vascular bundle especially in the peduncle is one of crucial limiting factors of rice yield, and it determines how plants efficiently transport photosynthetic products, mineral nutrients and water from leaf and root to panicle. However, the genetic base o...

  • Open Access English
    Authors: 
    Jia Zhao; Xu Zhang; Wentao Wan; Heng Zhang; Jia Liu; Mengli Li; Haiyan Wang; Jin Xiao; Xiue Wang;
    Publisher: Multidisciplinary Digital Publishing Institute

    The EXO70 gene family is involved in different biological processes in plants, ranging from plant polar growth to plant immunity. To date, analysis of the EXO70 gene family has been limited in Triticeae species, e.g., hexaploidy Triticum aestivum and its ancestral/relat...

  • Open Access English
    Authors: 
    Karen Kemirembe; Mynthia Cabrera; Liwang Cui;
    Publisher: Elsevier
    Project: NIH | Malaria Epidemiology in S... (5U19AI089672-03)

    The 8-aminoquinoline tafenoquine (TFQ), a primaquine derivative, is currently in late-stage clinical development for the radical cure of P. vivax. Here drug interactions between TFQ and chloroquine and six artemisinin-combination therapy (ACT) partner drugs in P. falcip...

  • Publication . Article . Other literature type . 2017
    Open Access English
    Authors: 
    Brown, David K.; Tastan Bishop, Özlem;

    The completion of the human genome project at the beginning of the 21st century, along with the rapid advancement of sequencing technologies thereafter, has resulted in exponential growth of biological data. In genetics, this has given rise to numerous variation databas...

  • Open Access
    Authors: 
    Jianyong Xu; Wei Lian; Lingyun Li; Zhong Huang;
    Publisher: Impact Journals, LLC

    // Jianyong Xu 1,2,3 , Wei Lian 1,2,3 , Lingyun Li 1,2,3 and Zhong Huang 1,2,3 1 Institute of Biological Therapy, Shenzhen University, Shenzhen, China 2 Department of Pathogen Biology and Immunology, Shenzhen University School of Medicine, Shenzhen, China 3 Shenzhen Cit...

  • Open Access
    Authors: 
    Paola Maroni; Emanuela Matteucci; Paola Bendinelli; Maria Alfonsina Desiderio;
    Publisher: MDPI AG
    Country: Italy

    Epigenetic mechanisms influence molecular patterns important for the bone-metastatic process, and here we highlight the role of WW-domain containing oxidoreductase (Wwox). The tumor-suppressor Wwox lacks in almost all cancer types; the variable expression in osteosarcom...

  • Open Access
    Authors: 
    Geng, Chuandong; Kaochar, Salma; Li, Min; Rajapakshe, Kimal; Fiskus, Warren; Dong, Jianrong; Foley, Christopher; Dong, Boming; Zhang, Li; Kwon, Oh-Joon; +7 more
    Publisher: Springer Science and Business Media LLC
    Project: NIH | The Notch Signaling in Pr... (1R01CA190378-01A1), NIH | Baylor College of Medicin... (3P30CA125123-09S3), NIH | Diabetes Endocrinology Re... (1P30DK079638-01), NIH | BCM Oncology Scholars Tra... (5T32CA174647-03)

    The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either somatic mutations or mRNA downregulation, suggesting an important tumour suppressor function. To examine its physiologic role in the pr...

  • Authors: 
    Jean-Léon Maître;
    Publisher: EDP Sciences

    During the very first days of mammalian development, the embryo forms a structure called the blastocyst. The blastocyst consists of two cell types: the trophectoderm (TE), which implants the embryo in the uterus and the inner cell mass (ICM), which gives rise to all cel...

  • Open Access
    Authors: 
    Lewandowska, Dagmara W.; Zagordi, Osvaldo; Geissberger, Fabienne-Desirée; Kufner, Verena; Schmutz, Stefan; Böni, Jürg; Metzner, Karin J.; Trkola, Alexandra; Huber, Michael;
    Publisher: Zenodo
    Country: Switzerland

    Background Sequence-specific PCR is the most common approach for virus identification in diagnostic laboratories. However, as specific PCR only detects pre-defined targets, novel virus strains or viruses not included in routine test panels will be missed. Recently, adva...

  • Authors: 
    dos Anjos Silva, Lindomar; Divino, Flavia; da Silva Rêgo, Márlisson Octávio; Lima Lopes, Ivina Geselle; Nóbrega Costa, Cláudia Maria; da Silva Pereira, Francis Christian; de Filippis, Ivano; Bello, Gonzalo;
    Publisher: Mary Ann Liebert Inc

    The pattern of HIV-1 subtype distribution and prevalence of transmitted drug resistance mutations (TDRM) is heterogeneous across different Brazilian regions. Little information is available about the molecular epidemiologic profile in Northern Brazil. HIV-1 protease (PR...

  • Publication . Other literature type . Article . 2016
    Open Access English
    Authors: 
    Stubbendieck, Reed M.; Straight, Paul D.;
    Publisher: American Society for Microbiology

    ABSTRACT Microbial communities span many orders of magnitude, ranging in scale from hundreds of cells on a single particle of soil to billions of cells within the lumen of the gastrointestinal tract. Bacterial cells in all habitats are members of densely populated local...

  • Open Access English
    Authors: 
    Visser, Carina; Lashmar, Simon F.; Marle-Koster, Este Van; Poli, Mario Andres; Allain, Daniel;
    Publisher: Public Library of Science
    Country: France

    The Angora goat populations in Argentina (AR), France (FR) and South Africa (SA) have been kept geographically and genetically distinct. Due to country-specific selection and breeding strategies, there is a need to characterize the populations on a genetic level. In thi...

  • Open Access
    Authors: 
    Sheila R. Alcantara Llaguno; Xuanhua Xie; Luis F. Parada;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Cancer Biology Training G... (2T32CA124334-06), NIH | Genetic Mouse Models of G... (5R01CA131313-05)

    The cellular origins and the mechanisms of progression, maintenance of tumorigenicity, and therapeutic resistance are central questions in the glioblastoma multiforme (GBM) field. Using tumor suppressor mouse models, our group recently reported two independent populatio...

  • Open Access
    Authors: 
    Gouw, Joost W; Jo, Juandy; Meulenbroek, Laura A P M; Heijjer, T Sam; Kremer, Erica; Sandalova, Elena; Knulst, André C; Jeurink, Prescilla V; Garssen, Johan; Rijnierse, Anneke; +3 more
    Publisher: Wiley
    Country: Netherlands

    BACKGROUND: Failure to induce oral tolerance may result in food allergy. Hydrolysed cow's milk-based infant formulas are recommended in subjects with a high risk of developing allergic disease. Presentation of T cell epitopes is a prerequisite to generate regulatory T c...

  • Closed Access
    Authors: 
    Ricardo Durán; Jaime Zapata-Valenzuela; Claudio Balocchi; Sofía Valenzuela;
    Publisher: Springer Science and Business Media LLC

    EUChip60K is a good option to evaluate clonal identity in a breeding population of E. globulus. Breeding populations normally are composed of numerous progenies which become the base for the development of new genetic material for propagation and to advance generations ...

  • Open Access
    Authors: 
    April D. Lake; Alexandria L. Chaput; Petr Novák; Nathan J. Cherrington; Catharine L. Smith;
    Publisher: Elsevier BV

    The molecular mechanisms behind the transition from simple steatosis to nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease (NAFLD) are not clearly understood. This hinders development of effective therapies for treatment and prevention of NASH. In t...

  • Open Access English
    Authors: 
    Macchietto, Marissa; Angdembey, Dristi; Heidarpour, Negar; Serra, Lorrayne; Rodriguez, Bryan; El-Ali, Nicole; Mortazavi, Ali;
    Publisher: Oxford University Press
    Project: NIH | Comparative analysis of t... (1DP2GM111100-01)

    Abstract Cells express distinct sets of genes in a precise spatio-temporal manner during embryonic development. There is a wealth of information on the deterministic embryonic development of Caenorhabditis elegans, but much less is known about embryonic development in n...

  • Restricted English
    Authors: 
    Casas, François; Fouret, Gilles; Lecomte, Jérome; Cortade, Fabienne; Pessemesse, Laurence; Blanchet, Emilie; Wrutniak-Cabello, Chantal; Coudray, Charles; Feillet-Coudray, Christine;
    Publisher: HAL CCSD
    Country: France

    Thyroid hormone is a major regulator of metabolism and mitochondrial function. Thyroid hormone also affects reactions in almost all pathways of lipids metabolism and as such is considered as the main hormonal regulator of lipid biogenesis. The aim of this study was to e...

  • Open Access
    Authors: 
    Yulong Niu; Shayan Moghimyfiroozabad; Sepehr Safaie; Yi Yang; Elizabeth A. Jonas; Kambiz N. Alavian;
    Publisher: Springer Science and Business Media LLC
    Country: United Kingdom

    ATP synthase is a complex universal enzyme responsible for ATP synthesis across all kingdoms of life. The F-type ATP synthase has been suggested to have evolved from two functionally independent, catalytic (F1) and membrane bound (Fo), ancestral modules. While the modul...

  • Open Access English
    Authors: 
    Shiro Mawatari; Seira Hazeyama; Tomomi Morisaki; Takehiko Fujino;
    Publisher: Elsevier

    Objectives Ethanolamine ether phospholipids (ePE) and choline ether phospholipid (ePC) are present in human serum or plasma. Decreases in ether phospholipids (plasmalogens) in serum (plasma) have been reported in several diseases such as Alzheimer's disease, Parkinson's...

  • Closed Access
    Authors: 
    Nagel, Rebecca; Kirschbaum, Frank; Tiedemann, Ralph;
    Publisher: Springer Science and Business Media LLC

    In mormyrid weakly electric fish, the electric organ discharge (EOD) is used for species recognition, orientation and prey localization. Produced in the muscle-derived adult electric organ, the EOD exhibits a wide diversity across species in both waveform and duration. ...

  • Open Access English
    Authors: 
    Álvarez-Pérez, Sergio; Blanco, José L.; Astorga, Rafael J.; Gómez-Laguna, Jaime; Barrero-Domínguez, Belén; Galán-Relaño, Angela; Harmanus, Celine; Kuijper, Ed; García, Marta E.;
    Country: Netherlands

    The presence and genetic diversity of Clostridium difficile and C. perfringens along the slaughtering process of pigs reared in a free-range system was assessed. A total of 270 samples from trucks, lairage, slaughter line and quartering were analyzed, and recovered isol...

  • Open Access English
    Authors: 
    Shu Wen Qian; Yan Liu; Jue Wang; Ji Chan Nie; Meng yuan Wu; Yan Tang; Ya Xin Zhao; Xi Li; Hai Yan Huang; Liang Guo; +3 more
    Publisher: Elsevier

    Similar to estrogens, bone morphogenetic protein 4 (BMP4) promotes the accumulation of more metabolically active subcutaneous fat and reduction of visceral fat. However, whether there is a cross-talk between BMP4 and estrogen signaling remained unknown. Herein, we found...

  • Publication . Other literature type . Article . 2016
    Open Access English
    Authors: 
    Zhu, Heng; Wang, Guohua; Qian, Jiang;

    Recent technological advances have made it possible to decode DNA methylomes at single-base-pair resolution under various physiological conditions. Many aberrant or differentially methylated sites have been discovered, but the mechanisms by which changes in DNA methylat...

  • Open Access
    Authors: 
    Hui Xiong; Jiangnan Zhang;
    Publisher: Spandidos Publications

    The expression of ataxia-telangiectasia mutated (ATM) and p53 upregulated modulator of apoptosis (PUMA) genes in patients with colorectal cancer were investigated, to explore the correlation between the expression of ATM and PUMA and tumor development, to evaluate the c...

  • Open Access English
    Authors: 
    Loubna Abdel Hadi; Clara Di Vito; Laura Riboni;
    Country: Italy

    Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular ev...

  • Closed Access
    Authors: 
    Yu. Ya. Khrunyk; I. V. Vyalykh; A. V. Korelin; S. V. Belikov; M. S. Karabanalov; S. B. Rakitin; R. V. Kamalov; A. A. Popov;
    Publisher: Pleiades Publishing Ltd

    Methods for obtaining osteoblast cultures from the calvaria of adult Wistar rats and 12-day-old embryos of these rats have been adapted for studying the biocompatibility and ossointegration of titanium-based implants. The osteoblast morphology and their differentiation ...

  • Open Access
    Authors: 
    Alli Muthiah; Ramachandran Kandasamy; S Nagulan; Aruna Madasamy;
    Publisher: Medip Academy

    Background: Diabetes mellitus is characterized by high blood sugar levels over a prolonged period due to alteration in either the insulin secretion, insulin action, or both. Worldwide, as of the recent 2016 data collected from the World Health Organization (WHO) around ...

  • Open Access
    Authors: 
    Maciej Kotliński; Lukasz Knizewski; Anna Muszewska; Kinga Rutowicz; Maciej Lirski; Anja Schmidt; Célia Baroux; Krzysztof Ginalski; Andrzej Jerzmanowski;
    Publisher: Oxford University Press (OUP)
    Project: SNSF | Mechanisms and role of li... (31003A_149974)

    H1 (or linker) histones are basic nuclear proteins that possess an evolutionarily conserved nucleosome-binding globular domain, GH1. They perform critical functions in determining the accessibility of chromatin DNA to trans-acting factors. In most metazoan species studi...

  • Closed Access
    Authors: 
    Linda Andersson; Christina Drevinge; Ismena Mardani; Knut Tomas Dalen; Marcus Ståhlman; Martina Klevstig; Annika Lundqvist; Fred Haugen; Martin Adiels; Per Fogelstrand; +8 more
    Publisher: Elsevier BV

    Myocardial triglycerides stored in lipid droplets are important in regulating the intracellular delivery of fatty acids for energy generation in mitochondria, for membrane biosynthesis, and as agonists for intracellular signaling. Previously, we showed that deficiency i...

  • Closed Access
    Authors: 
    Alexandra T. Gruia; Maria Suciu; Lucian Barbu-Tudoran; Seyed Mohammad Reza Azghadi; Mirabela Cristea; Dragos V. Nica; Adrian Vaduva; Danina Muntean; Ani A. Mic; Felix A. Mic;
    Publisher: Wiley

    Adult bone marrow mesenchymal stromal cells (BMSCs) can easily be differentiated into a variety of cells. In vivo transplantation of BMSCs-differentiated cells has had limited success, suggesting that these cells may not be fully compatible with the cells they are inten...

  • Open Access English
    Authors: 
    Yeoun Joo Lee;
    Publisher: The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition

    Increased awareness of the importance of nutrition among hospitalized children has increased the use of nutrition screening tool (NST). However, it is not well known the NST for hospitalized children. Therefore, the purpose of this study is to understand the past and pr...

  • Authors: 
    Els Verhoeyen;
    Publisher: Bentham Science Publishers Ltd.
  • Open Access

    The human amniotic fluid stem cell (hAFSC) population consists of two morphologically distinct subtypes, spindle-shaped and round-shaped cells (SS-hAFSCs and RS-hAFSCs). Whilst SS-hAFSCs are routinely expanded in mesenchymal-type (MT) conditions, we previously showed th...

  • Open Access English
    Authors: 
    Larjo, Antti; Eveleigh, Robert; Kilpeläinen, Elina; Kwan, Tony; Pastinen, Tomi; Koskela, Satu; Partanen, Jukka;
    Publisher: Frontiers Media S.A.

    The human leukocyte antigen (HLA) genes code for proteins that play a central role in the function of the immune system by presenting peptide antigens to T cells. As HLA genes show extremely high genetic polymorphism, HLA typing at the allele level is demanding and is b...

  • Open Access
    Authors: 
    Julia Günter; Petra Wolint; Annina Bopp; Julia Steiger; Elena Cambria; Simon P. Hoerstrup; Maximilian Y. Emmert;
    Publisher: Hindawi Limited
    Country: Switzerland

    More people die annually from cardiovascular diseases than from any other cause. In particular, patients who suffer from myocardial infarction may be affected by ongoing adverse remodeling processes of the heart that may ultimately lead to heart failure. The introductio...

  • Open Access English
    Authors: 
    Lance A. Stechschulte; Chunxi Ge; Terry D. Hinds; Edwin R. Sanchez; Renny T. Franceschi; Beata Lecka-Czernik;
    Publisher: American Society for Biochemistry and Molecular Biology

    Peroxisome proliferator-activated receptor γ (PPARγ) and runt-related transcription factor 2 (RUNX2) are key regulators of mesenchymal stem cell (MSC) differentiation toward adipocytes and osteoblasts, respectively. Post-translational modifications of these factors dete...

  • Open Access English
    Authors: 
    Ping Sun; Chenling Zhang; Mujia Pang; Lifu Qian; Tao Pan; Hui Wang; Baowei Zhang;
    Publisher: Taylor & Francis

    Abstract Anthus hodgsoni is a species of small passerine bird in the family Motacillidae, which is widely distributed. In this study, we determined the complete mitochondrial genome of A. hodgsoni. The result showed that the total length of the mitochondrial genome was ...

  • Publication . Article . 2018
    Closed Access
    Authors: 
    Jack M Heintze;
    Publisher: Springer Science and Business Media LLC
  • Open Access English
    Authors: 
    Alexandre Vallée; Jean-Noël Vallée;
    Publisher: BioMed Central

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disease which is characterized by a deficit in social interactions and communication with repetitive and restrictive behavior. In altered cells, metabolic enzymes are modified by the dysregulation of the ca...

  • Publication . Article . Other literature type . 2015
    Open Access English
    Authors: 
    Teresa Ferraro; Emilia Esposito; Laure Mancini; Sam Ng; Tanguy Lucas; Mathieu Coppey; Nathalie Dostatni; Aleksandra M. Walczak; Michael Levine; Mounia Lagha;
    Publisher: HAL CCSD
    Country: France
    Project: ANR | DEEP (ANR-11-LABX-0044)

    International audience; Transmission of active transcriptional states from mother to daughter cells has the potential to foster precision in the gene expression programs underlying development. Such transcriptional memory has been specifically proposed to promote rapid ...

  • Open Access English
    Authors: 
    Le Vee, Marc; Jouan, Elodie; Lecureur, Valérie; FARDEL, Olivier;
    Publisher: HAL CCSD
    Country: France

    International audience; The heterodimeric L-type amino acid transporter (LAT) 1/ CD98hc is overexpressed in lung cancers with a poor prognosis factor. Factors that contribute to LAT1/CD98hc overexpression in lung cells remain however to be determined, but the implicatio...

  • Open Access
    Authors: 
    Anthony A. Wright;
    Publisher: Elsevier BV

    Summary Rats exposed to variable-length, unique-odor lists were tested in distinctive contexts for odors second or forth from list-end. Accurate ability to recall odors backwards from the end of lists points to their ability to manipulate and replay odor-list episodic m...

  • Open Access
    Authors: 
    McKinnell, James A; Connolly, Lynn E; Pushkin, Richard; Jubb, Adrian M; O’Keeffe, Bridget; Serio, Alisa W; Smith, Alex; Gall, Jonathan; Riddle, Valerie; Krause, Kevin M; +1 more
    Publisher: Oxford University Press (OUP)
  • Open Access English
    Authors: 
    Aras, Betül Senay; Zhou, Y. C.; Dawes, Adriana; Chou, Ching-Shan;
    Publisher: Public Library of Science (PLoS)
    Project: NSF | CAREER: Spatial Modeling ... (1253481), NSF | CAREER: Multiscale invest... (1554896)

    Intracellular polarization, where a cell specifies a spatial axis by segregation of specific factors, is a fundamental biological process. In the early embryo of the nematode worm Caenorhabditis elegans (C. elegans), polarization is often accompanied by deformations of ...

  • Closed Access
    Authors: 
    Hao, Jing; Duan, Fei-Fei; Wang, Yangming;
    Publisher: Elsevier BV

    Post-transcriptional and translational regulations play essential roles during cellular reprogramming and in the maintenance and differentiation of pluripotent stem cells (PSCs). MicroRNAs (miRNAs) control cell cycle, glycolysis, chromatin state, survival and pluripoten...

  • Open Access
    Authors: 
    Mengmeng Yang; Fang Liang; Defeng Xu; Yue Wang; Huan Zhou; Darcy E Wagner; Lei Liu;
    Publisher: Macrothink Institute, Inc.

    Airway smooth muscle cells (ASMCs) have been recommended as a target for the treatment of inflammation and narrowing of the airways in asthma. New safe and efficient approaches to relieve symptoms caused by ASMCs is highly desired. Inspired by the inhibitory effects of ...

  • Publication . Article . 2016
    Closed Access
    Authors: 
    S. Greven; Jochen Brasch; U. Reusch; M. Reusch; Volker Mielke;
    Publisher: Springer Science and Business Media LLC

    In the event of non-specific epidermal lesions, the importance of a comprehensive anamnesis becomes especially apparent. In the following, we report on a patient case in which only a focused anamnesis was able to bring light into the darkness of numerous differential di...

  • Open Access
    Authors: 
    Aharon Oren; George M. Garrity;
    Publisher: Microbiology Society
  • Publication . Article . Other literature type . 2017
    Open Access
    Authors: 
    Shin-ei Kudo; Toyoki Kudo;
    Publisher: AME Publishing Company

    In association with the growing elderly population, the rates of colorectal cancer are increasing worldwide. Thus, the need for total colonoscopy in the elderly can be expected to increase accordingly with this trend. The World Health Organization defines the “elderly” ...