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  • Open Access
    Authors: 
    Misra, N.; Pu, X.; Holt, D. N.; McGuire, M. A.; Tinker, J. K.;
    Publisher: American Dairy Science Association
    Project: NSF | MRI: Acquisition of an LC... (0923535), NSF | Acquisition of a Confocal... (0619793)

    Staphylococcus aureus is an opportunistic pathogen affecting both human and animal species. An effective vaccine to prevent S. aureus bovine disease and transmission would have positive effects on animal well-being, food production, and human health. The objective of th...

  • Publication . Other literature type . Preprint . Article . 2016
    Open Access English
    Authors: 
    Mirjana Domazet-Lošo; Tomislav Domazet-Lošo;
    Country: Croatia

    AbstractProkaryotic and viral genomes are often altered by recombination and horizontal gene transfer. The existing methods for detecting recombination are primarily aimed at viral genomes or sets of loci, since the expensive computation of underlying statistical models...

  • Open Access English
    Authors: 
    Toreno, Georgia; Isola, Daniela; Meloni, Paola; Carcangiu, Gianfranco; Selbmann, Laura; Onofri, Silvano; Caneva, Giulia; Zucconi, Laura;
    Country: Italy

    Abstract In restoration and conservation practices, biocide treatments are considered one of the most practical approaches to remove biological colonization on artworks, including stone. Numerous studies have focused on the short- and long-term effects of these treatmen...

  • Authors: 
    Michaela Defrancesco;
    Publisher: BMJ

    ABSTRACT FROM: Cooper C, Sommerlad A, Lyketsos CG, et al . Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry 2015;172:323–34. The long ‘preclinical’ phase including mild cognitive impairment-stage (MCI...

  • Open Access
    Authors: 
    Tiago R. Matos; John T. O'Malley; E.L. Lowry; D. Hamm; I.R. Kirsch; Harlan Robins; Thomas S. Kupper; James G. Krueger; Rachael A. Clark;
    Publisher: Elsevier BV
  • Authors: 
    Fangxia Guo; Yongdong Liu; Chun Zhang; Qi Wang; Lianyan Wang; Yuhui Gao; Jingxiu Bi; Heng Wang; Zhiguo Su;
    Publisher: American Chemical Society (ACS)

    As one of the pathogen-associated molecular patterns (PAMPs), flagellin is recently utilized as a potent adjuvant for many subunit vaccines. In this study, a truncated flagellin (tFL) with deletion of the hypervariable regions was adopted as a carrier–adjuvant by chemic...

  • Authors: 
    Sajjad Ahrari; Navid Mogharrab; Leila Navapour;
    Publisher: Informa UK Limited

    Microtubule affinity-regulating kinase 4 (MARK4) is a serine/threonine protein kinase belonging to a highly-conserved group of PAR proteins that phosphorylate microtubule-associated proteins (tau, MAP2 and MAP4) and regulate cell polarity. MARK4 isoform is mainly found ...

  • Open Access English
    Authors: 
    Litao Zhang;
    Publisher: Wiley

    Abstract We appreciate the opportunity to respond to the letter from Dr Gris and colleagues. It is true there were several limitations in our study. However, we still believe that D‐dimer level at admission could be an effective and easily available predictor in patient...

  • Open Access
    Authors: 
    Beth M. Moscato; Monalisa Swain; J. Patrick Loria;
    Publisher: American Chemical Society (ACS)

    DNA polymerase β (Pol β) repairs single-nucleotide gapped DNA (sngDNA) by enzymatic incorporation of the Watson−Crick partner nucleotide at the gapped position opposite the templating nucleotide. The process by which the matching nucleotide is incorporated into a sngDNA...

  • Open Access
    Authors: 
    Joshua C. Drake; Zhen Yan;
    Publisher: Wiley

    Skeletal muscle is important for overall functionality and health. Ageing is associated with an accumulation of damage to mitochondrial DNA and proteins. In particular, damage to mitochondrial proteins in skeletal muscle, which is a loss of mitochondrial proteostasis, c...

  • Open Access
    Authors: 
    James Lindesay; Tshela E. Mason; William Hercules; Georgia M. Dunston;
    Publisher: Scientific Research Publishing, Inc.

    As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaptation that optimizes population survival in differing environments. This paper mathematically models environmentally induced ad...

  • Authors: 
    Malcolm L. Beck; Jill T. Hardman; Alicia M. Briseño;
    Publisher: Walter de Gruyter GmbH

    The purpose of the study was to evaluate the feasibility of substituting the Immucor Capture-R solid phase (SP) antibody detection system for our routine donor antibody screen. Our routine procedure (RP) used a 12-drop pool of six donor sera and one drop of pooled reage...

  • Publication . Article . 2016
    Closed Access
    Authors: 
    Julian I. Rood; Bruce A. McClane; Kaori Ohtani;
    Publisher: Elsevier BV
  • Authors: 
    Donna Hubbard McCree; Harrell W. Chesson; Samuel T Eppink; Linda Beer; Kirk D. Henny;
    Publisher: Ovid Technologies (Wolters Kluwer Health)

    Background Diagnoses of HIV infection among male adults and adolescents ≥13 years with infection attributed to heterosexual contact decreased from 2014 through 2018. Racial disparities exist; HIV diagnoses are higher among Black/African American men compared with men of...

  • Publication . Article . 2016
    Open Access
    Authors: 
    Ned Stafford;
    Publisher: BMJ

    Pioneer of cancer genetics who developed the groundbreaking “two hit” hypothesis As a teenager growing up in Los Angeles in the late 1930s, Alfred G Knudson loved physics, chemistry, and mathematics. Biology did not interest him much. When he enrolled at the California ...

  • Open Access
    Authors: 
    Aarnoutse, R.E.; Kibiki, G.S.; Reither, K.; Semvua, H.H.; Haraka, F.; Mtabho, C.M.; Mpagama, S.G.; Boogaard, J. van den; Sumari-de Boer, I.M.; Magis-Escurra, C.; +9 more
    Country: Netherlands

    ABSTRACT In a multiple-dose-ranging trial, we previously evaluated higher doses of rifampin in patients for 2 weeks. The objectives of the current study were to administer higher doses of rifampin for a longer period to compare the pharmacokinetics, safety/tolerability...

  • Open Access
    Authors: 
    Srinivas Niranj Chandrasekaran; Charles W. Carter;
    Publisher: AIP Publishing

    PATH algorithms for identifying conformational transition states provide computational parameters—time to the transition state, conformational free energy differences, and transition state activation energies—for comparison to experimental data and can be carried out su...

  • Open Access English
    Authors: 
    Colin A. Johnson; Spencer J. Collis;
    Publisher: BioMed Central
    Country: United Kingdom
    Project: WT , EC | SYSCILIA (241955), UKRI | Functional genomics ident... (MR/M000532/1)

    Both inherited and sporadic mutations can give rise to a plethora of human diseases. Through myriad diverse cellular processes, sporadic mutations can arise through a failure to accurately replicate the genetic code or by inaccurate separation of duplicated chromosomes ...

  • Open Access
    Authors: 
    Ju, H-Q; Zhan, G; Huang, A; Sun, Y; Wen, S; Yang, J; Lu, W-h; Xu, R-h; Li, J; Li, Y; +3 more
    Publisher: Springer Science and Business Media LLC

    Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD) represents an unfavorable genetic change in acute myeloid leukemia (AML) and is associated with poor prognosis. Metabolic alterations have been involved in tumor progression and att...

  • Open Access
    Authors: 
    Joseph Ndunguru; Leandro De León; Catherine D. Doyle; Peter Sseruwagi; Germán Plata; James P. Legg; Graham Thompson; Joe Tohme; Theresa A. S. Aveling; J. T. Ascencio-Ibanez; +1 more
    Publisher: American Society for Microbiology
    Project: NSF | BREAD: Functional Analysi... (1110050)

    ABSTRACT Cassava mosaic begomoviruses (CMBs) cause cassava mosaic disease (CMD) across Africa and the Indian subcontinent. Like all members of the geminivirus family, CMBs have small, circular single-stranded DNA genomes. We report here the discovery of two novel DNA s...

  • Open Access English
    Authors: 
    Elena Alexandrova; Nicola Miglino; Adnan Hashim; Giovanni Nassa; Claudia Stellato; Michael Tamm; Florence Baty; Martin Brutsche; Alessandro Weisz; Pieter Borger;
    Country: Switzerland
    Project: SNSF | Die Suche nach regulatori... (310030_133109)

    Background Aberrant expression of small noncoding RNAs (sncRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs) in particular, define several pathologic processes. Asthma is characterized by airway hyperreactivity, chronic inflammation, and airway wall remodelin...

  • Open Access
    Authors: 
    Barbara Banelli; Antonio Daga; Alessandra Forlani; Giorgio Allemanni; Daniela Marubbi; Maria Pia Pistillo; Aldo Profumo; Massimo Romani;
    Publisher: Impact Journals, LLC

    // Barbara Banelli 1, 2, * , Antonio Daga 3, * , Alessandra Forlani 1, * , Giorgio Allemanni 1 , Daniela Marubbi 3, 4 , Maria Pia Pistillo 1 , Aldo Profumo 5 , Massimo Romani 1 1 Laboratory of Tumor Epigenetics, IRCCS AOU San Martino–IST, Genova, Italy 2 Department of H...

  • Open Access
    Authors: 
    McLoughlin, K; Schluter, J; Rakoff-Nahoum, S; Smith, AL; Foster, KR;
    Publisher: Elsevier BV
    Country: United Kingdom
    Project: EC | INTERACTINGMICROBES (242670)

    The host epithelium is the critical interface with microbial communities, but the mechanisms by which the host regulates these communities are poorly understood. Here we develop the hypothesis that hosts use differential adhesion to select for and against particular mem...

  • Open Access English
    Authors: 
    Hyunook Kang; Injin Bang; Kyeong Sik Jin; Boyun Lee; Junho Lee; Xiangqiang Shao; Jonathon A. Heier; Adam V. Kwiatkowski; W. James Nelson; Jeff Hardin; +2 more
    Publisher: American Society for Biochemistry and Molecular Biology

    Intercellular epithelial junctions formed by classical cadherins, β-catenin, and the actin-binding protein α-catenin link the actin cytoskeletons of adjacent cells into a structural continuum. These assemblies transmit forces through the tissue and respond to intracellu...

  • Publication . Article . 2018
    Authors: 
    Albrecht Wienke;
    Publisher: Georg Thieme Verlag KG

    Die Patientenaufklarung ist mittlerweile auch in Arztkreisen zu einer allseits anerkannten und zentralen arztlichen Verpflichtung geworden. Die Patientenaufklarung in Klinik und Praxis zahlt neben der standardgemasen Behandlung und der Dokumentation zu den Kardinalpflic...

  • Closed Access
    Authors: 
    Wancai Xing; Meng Li; Fayou Zhang; Xing Ma; Jiafu Long; Hao Zhou;
    Publisher: Elsevier BV

    Merlin functions as a tumor suppressor and suppresses malignant activity of cancer cells through multiple mechanisms. However, whether Serine 518 phosphorylation regulates the conformation of Merlin as well as the open-closed conformational changes affect Merlin's tumor...

  • Open Access
    Authors: 
    Tiancheng Zhou; Caihua Xiong; Juanjuan Zhang; Wenbin Chen; Xiaolin Huang;
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    Researchers have found that the walking economy can be enhanced by recycling ankle metabolic energy using an unpowered ankle exoskeleton. However, how to regulate multiarticular energy to enhance the overall energy efficiency of humans during walking remains a challengi...

  • Open Access English
    Authors: 
    Lucía Sanjurjo; Lucía Sanjurjo; Gemma Aran; Érica Téllez; Núria Amézaga; Carolina Armengol; Carolina Armengol; Daniel López; Clara Prats; Maria-Rosa Sarrias; +1 more
    Country: Spain

    CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to T...

  • Open Access English
    Authors: 
    Lécuyer, Hervé; Virion, Zoé; Barnier, Jean-Philippe; Matczak, Soraya; Bourdoulous, Sandrine; Bianchini, Elsa; Saller, François; Borgel, Delphine; Nassif, Xavier; Coureuil, Mathieu;
    Publisher: HAL CCSD
    Country: France
    Project: ANR | BactInfectERA (ANR-14-IFEC-0006)

    Purpura fulminans is a deadly complication of Neisseria meningitidis infections due to extensive thrombosis of microvessels. Although a Disseminated Intra-vascular Coagulation syndrome (DIC) is frequently observed during Gram negative sepsis, it is rarely associated wit...

  • Open Access English
    Authors: 
    Chiung-Hung Hsu; Chia-Wei Hsu; Chuen Hsueh; Chih-Liang Wang; Yi-Cheng Wu; Chih-Ching Wu; Chin-Ching Liu; Jau-Song Yu; Yu-Sun Chang; Chia-Jung Yu;
    Publisher: The American Society for Biochemistry and Molecular Biology

    Lung cancer is the leading cause of cancer-related death worldwide. Both diagnostic and prognostic biomarkers are urgently needed to increase patient survival. In this study, we identified/quantified 1763 proteins from paired adenocarcinoma (ADC) tissues with different ...

  • Open Access
    Authors: 
    Barbara Pergolizzi; Salvatore Bozzaro; Enrico Bracco;
    Publisher: UPV/EHU Press
    Country: Italy

    By protein quality control and degradation, the ubiquitin system drives many essential regulatory processes such as cell cycle and division, signalling, DNA replication and repair. Therefore, dysfunctions in the ubiquitin system lead to many human disease states. Howeve...

  • Publication . Article . 2015
    Closed Access
    Authors: 
    Min Zhang; Ling-Long Peng; Ying Wang; Jian-Shu Wang; Jiao Liu; Meng-Meng Liu; Jia Hu; Bin Song; Hai-Bing Yang;
    Publisher: Springer Science and Business Media LLC

    A20 (TNFAIP3), known to inhibit NF-κB function by deubiquitinating-specific NF-κB signaling molecules, has been found in many cell types of the immune system. Recent findings suggest that A20 is essential for the development and functional performance of dendritic cell,...

  • Closed Access French
    Authors: 
    Vinciguerra, A.; Réveillère, C.; Potard, C.; Lyant, B.; Cornu, L.; Courtois, R.;
    Publisher: HAL CCSD
    Country: France

    L'Encephale - Sous presse. Epreuves corrigees par l'auteur. Disponible en ligne depuis le jeudi 11 octobre 2018

  • Publication . Other literature type . Article . 2018
    Open Access English
    Authors: 
    Bowen, William S.; Svrivastava, Abhishek K.; Batra, Lalit; Barsoumian, Hampartsoum; Shirwan, Haval;

    Introduction: Although much progress has been made in the last decade(s) toward development of effective cancer vaccines, there are still important obstacles to therapeutic successes. New generatio...

  • Open Access English
    Authors: 
    Araceli Lamelas; Kobina Assan Ampah; Samuel Yaw Aboagye; Sarah Kerber; Emelia Danso; Adwoa Asante-Poku; Prince Asare; Julian Parkhill; Simon R. Harris; Gerd Pluschke; +2 more
    Publisher: Public Library of Science
    Country: Switzerland
    Project: WT

    Author Summary Infection with Mycobacterium ulcerans causes the debilitating skin disease Buruli ulcer. Until today, transmission pathways and reservoirs of this emerging pathogen are not well understood. Generally, it is assumed that infection occurs after contact with...

  • Open Access English
    Authors: 
    Masashi Utsumi; Hideki Aoki; Seichi Nagahisa; Seitaro Nishimura; Yuta Une; Yuji Kimura; Megumi Watanabe; Fumitaka Taniguchi; Takashi Arata; Koh Katsuda; +1 more
    Publisher: International Institute of Anticancer Research

    Background/Aim: The C-reactive protein (CRP) to albumin ratio (CAR) is associated with outcomes in patients with sepsis. We aimed to evaluate the significance of preoperative CAR in therapeutic outcomes after gallbladder carcinoma (GBC) resection. Patients and Methods: ...

  • Publication . Article . 2017
    Authors: 
    Robert E. Ulanowicz;
    Publisher: Philosophy Documentation Center
  • Open Access English
    Authors: 
    Tian, Lei; Shao, Xinghua; Xie, Yuanyuan; Wang, Qin; Che, Xiajing; Zhang, Minfang; Xu, Weijia; Xu, Yao; Mou, Shan; Ni, Zhaohui;
    Publisher: Cell Physiol Biochem Press GmbH & Co KG

    Background/Aims: Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after injury and is usually regarded as an early biomarker of acute kidney injury(AKI). The aim of this study was to determine the role of KIM-1 in the development of renal tubu...

  • Open Access English
    Authors: 
    Roger Benoit;
    Publisher: MDPI AG

    Botulinum neurotoxins (BoNTs) rank amongst the most potent toxins known. The factors responsible for the emergence of the many known and yet unknown BoNT variants remain elusive. It also remains unclear why anaerobic bacteria that are widely distributed in our environme...

  • Open Access English
    Authors: 
    Hao Zhang; Zheng Xing; Saravana Kumar Kailasam Mani; Brigitte Bancel; David Durantel; Fabien Zoulim; Elizabeth J. Tran; Philippe Merle; Ourania M. Andrisani;
    Publisher: John Wiley and Sons Inc.
    Country: France
    Project: NIH | CORE--DNA ANALYSIS (3P30CA023168-20S1), NIH | Role of CREB/ATF Proteins... (5R01DK044533-12), NIH | The Role of DEAD-box Prot... (5R01GM097332-03)

    Chronic hepatitis B virus (HBV) infection is a major factor in hepatocellular carcinoma (HCC) pathogenesis by a mechanism not yet understood. Elucidating mechanisms of HBV-mediated hepatocarcinogenesis is needed to gain insights into classification and treatment of HCC....

  • Open Access English
    Authors: 
    Xingguo Zhu; Biaoru Li; Betty S. Pace;
    Publisher: Ferrata Storti Foundation

    Sickle cell disease (SCD) is an inherited blood disorder resulting from an A to T mutation in codon 6 of the β-globin gene leading to hemoglobin S synthesis which undergoes polymerization under low oxygen conditions. Among different treatment strategies investigated in ...

  • Open Access
    Authors: 
    Shushi Nagamori; Pattama Wiriyasermkul; Meritxell Espino Guarch; Hirohisa Okuyama; Saya Nakagomi; Kenjiro Tadagaki; Yumiko Nishinaka; Susanna Bodoy; Kazuaki Takafuji; Suguru Okuda; +5 more
    Publisher: Proceedings of the National Academy of Sciences

    Heterodimeric amino acid transporters play crucial roles in epithelial transport, as well as in cellular nutrition. Among them, the heterodimer of a membrane protein b(0,+)AT/SLC7A9 and its auxiliary subunit rBAT/SLC3A1 is responsible for cystine reabsorption in renal p...

  • Open Access English
    Authors: 
    Haring, Martijn T.; Liv, Nalan; Zonnevylle, A. Christiaan; Narvaez, Angela C.; Voortman, Lenard M.; Kruit, Pieter; Hoogenboom, Jacob P.;
    Publisher: Nature Publishing Group
    Country: Netherlands

    In the biological sciences, data from fluorescence and electron microscopy is correlated to allow fluorescence biomolecule identification within the cellular ultrastructure and/or ultrastructural analysis following live-cell imaging. High-accuracy (sub-100 nm) image ove...

  • Open Access
    Authors: 
    Ghosh, Soumya; Persad, Emma; Shiue, Ting-Yun; Lam, Cindy; Islam, Afsana; Mascibroda, Lauren; Sherman, Michael; Smith, Thomas; Cheeptham, Naowarat;
    Publisher: MDPI AG

    Bacteriophages screened and isolated from sewage water samples exhibited antibacterial activities against multi-drug-resistant Escherichia coli strains. Five different water samples from Canadian habitats such as Kamloops Wastewater Treatment Center, Domtar, the Pacific...

  • Open Access English
    Authors: 
    Peón, Antonio; Naulaerts, Stefan; Ballester, Pedro J.;
    Publisher: Nature Publishing Group UK
    Country: France
    Project: ANR | Amidex (ANR-11-IDEX-0001)

    International audience; Many computational methods to predict the macromolecular targets of small organic molecules have been presented to date. Despite progress, target prediction methods still have important limitations. For example, the most accurate methods implicit...

  • Open Access
    Authors: 
    Ma, Wenjing; Zhao, Xiaoping; Wang, Kaiying; Liu, Jianjun; Huang, Gang;
    Publisher: Informa UK Limited

    Combination chemotherapy is a potentially promising approach to enhance anticancer activity, overcome drug resistance, and improve disease-free and overall survival. The current study investigates the antitumor activity of sodium dichloroacetic acid (DCA) in combination...

  • Open Access English
    Authors: 
    Matthew W. Fields; Paul J. Sturman; Skip Anderson;
    Publisher: Elsevier

    The Center for Biofilm Engineering was the first center of excellence focused on biofilms and was originally funded through the Engineering Research Center Program from the U.S. National Science Foundation. After almost 30 years, biofilm continues to be a stand-alone sc...

  • Closed Access
    Authors: 
    Sugrue, Michael; Sahebally, Shaheel Mohammad; Ansaloni, Luca; Zielinski, Martin; Coccolini, Federico;
    Publisher: Elsevier BV
  • Publication . Part of book or chapter of book . 2020
    Closed Access
    Authors: 
    Barbara Bartolini; Elena Caravà; Ilaria Caon; Arianna Parnigoni; Paola Moretto; Alberto Passi; Davide Vigetti; Manuela Viola; Evgenia Karousou;
    Publisher: Springer International Publishing

    The biology of tumor cells strictly depends on their microenvironment architecture and composition, which controls the availability of growth factors and signaling molecules. Thus, the network of glycosaminoglycans, proteoglycans, and proteins known as extracellular mat...

  • Open Access English
    Authors: 
    Angelina A. Kislichkina; Aleksandr G. Bogun; Lidiya A. Kadnikova; Nadezhda V. Maiskaya; Viktor I. Solomentsev; Mikhail E. Platonov; Svetlana V. Dentovskaya; Andrey P. Anisimov;
    Publisher: American Society for Microbiology

    ABSTRACT We here report the draft genome sequences of 8 Yersinia pestis subsp. microtus bv. caucasica strains isolated from the East Caucasian (previous name, Dagestan) mountain focus (no. 39), representing the most ancient branch of the 0.PE2 phylogroup circulating in...