Materials of the 6th All-Russian Conference on Molecular Oncology.Moscow, 21–23 December 2021

Breast cancer (BC) is the most common cancer among women in Russia. One of the main treatment methods of BC is systemic chemotherapy. Multidrug resistance of tumor cells (MDR) is the important hindrance on the way to successful chemotherapy. The new data concerning mole...

Objective: to study the sensitivity of gastrointestinal stromal tumors (GISTs) to the topoisomerases type II inhibitors and ability of imatinib to enhance GISTs sensitivity to the chemotherapeutic drugs indicated above. Subjects and Methods. We studied the sensitivity o...

Currently, treatment and diagnostics of neuroendocrine tumors are associated with a number of problems, including absence of a registry for these diseases. The article considers the main approaches and problems of immunohistochemical diagnostics of neuroendocrine tumors...

Bone metastasis is one of the most frequent and dangerous complications of malignant tumors. The last years, achievements in the study of bone remodeling mechanisms promoted the search of sensitive and specific criteria reflecting the intensity of osteolysis and osteosy...

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Wnt cascade is one of the most important signal pathways in the cell, which is required for normal embryonic development, differentiation, maintenance of stem cell phenotype and migration. Mutations in this pathway are associated with tumor growth (especially with colon...

There are a lot of studies that dedicated to genetic differences between the primary tumor and metastases. This becomes relevant not only for molecular biologists for understanding carcinogenesis, but also becoming increasingly important for medical oncologists, due to ...

Contrary to the generally accepted opinion about stable DNA as the carrier of hereditary information, in a normal (not just cancer) cell, this molecule is subject to the continuous changes as a result of copying errors (in the course of replication), defects of chromoso...