The paper gives an update on the pathogenesis of osteoarthrosis, the role of anti-inflammatory cytokines in the destruction of cartilage and subchondral bone, and the possibility of targeted diacerein therapy.

Glucocorticoids (GC) are extensively used to treat patients with systemic rheumatic diseases, which can improve their quality of life and substantially increase its span. At the same time their use is associated with the development of serious adverse reactions that can...