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977 publications, page 1 of 98
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  • Article English OPEN
    Annie Mayence; Jean Jacques Vanden Eynde;
    (2019)
    Tafenoquine (an 8-aminoquinoline) was approved by the Food and Drug Administration (FDA) in 2018 for the radical cure of <i>Plasmodium vivax</i> malaria and preventive action against malaria. Despite the fact that the mechanism of action of the drug remains unclear, all...
  • Other literature type English OPEN
    Vishnepolsky, Boris; Zaalishvili, George; Karapetian, Margarita; Nasrashvili, Tornike; Kuljanishvili, Nato; Gabrielian, Andrei; Rosenthal, Alex; Hurt, Darrell E.; Tartakovsky, Michael; Grigolava, Maya; Pirtskhalava, Malak;
    (2019)
    Antimicrobial peptides (AMPs) have been identified as a potentially new class of antibiotics to combat bacterial resistance to conventional drugs. The design of de novo AMPs with high therapeutic indexes, low cost of synthesis, high resistance to proteases and high bioa...
  • Other literature type, Article English OPEN
    Greenhill, Katherine; Hornsby, Erin; Gorman, Greg;
    (2019)
    Many pediatric intensive care patients require numerous specialized intravenous (IV) medications at various dosages in multiple fluids often with nutritional support. This requires several venous access points due to lack of Y-site compatibility data for combinations of...
  • Article English OPEN
    Ludovico Abenavoli; Tetyana Falalyeyeva; Luigi Boccuto; Olena Tsyryuk; Nazarii Kobyliak;
    (2018)
    The main treatments for patients with nonalcoholic fatty liver disease (NAFLD) are currently based on lifestyle changes, including ponderal decrease and dietary management. However, a subgroup of patients with nonalcoholic steatohepatitis (NASH), who are unable to modif...
  • Article English OPEN
    Farzana Hossain; Peter R. Andreana;
    (2019)
    Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been prioritized for th...
  • Article English OPEN
    Stefania Recalcati; Elena Gammella; Gaetano Cairo;
    (2019)
    Over the last decade, increasing evidence has reinforced the key role of metabolic reprogramming in macrophage activation. In addition to supporting the specific immune response of different subsets of macrophages, intracellular metabolic pathways also directly control ...
  • Article English OPEN
    João Antônio Leal de Miranda; João Erivan Façanha Barreto; Dainesy Santos Martins; Paulo Vitor de Souza Pimentel; Deiziane Viana da Silva Costa; Reyca Rodrigues e Silva; Luan Kelves Miranda de Souza; Camila Nayane de Carvalho Lima; Jefferson Almeida Rocha; Ana Paula Fragoso de Freitas; Durcilene Alves da Silva; Ariel Gustavo Scafuri; Renata Ferreira de Carvalho Leitão; Gerly Anne de Castro Brito; Jand Venes Rolim Medeiros; ...
    (2019)
    Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the effect of CG ex...
  • Article English OPEN
    Nyamdelger Sukhbaatar; Thomas Weichhart;
    (2018)
    Macrophages are sentinel cells of the innate immune system and have important functions in development, tissue homeostasis, and immunity. These phylogenetically ancient cells also developed a variety of mechanisms to control erythropoiesis and the handling of iron. Red ...
  • Other literature type, Article English OPEN
    Makharza, Sami A.; Cirillo, Giuseppe; Vittorio, Orazio; Valli, Emanuele; Voli, Florida; Farfalla, Annafranca; Curcio, Manuela; Iemma, Francesca; Nicoletta, Fiore Pasquale; El-Gendy, Ahmed A.; Goya, Gerardo F.; Hampel, Silke;
    (2019)
    Selective vectorization of Cisplatin (CisPt) to Glioblastoma U87 cells was exploited by the fabrication of a hybrid nanocarrier composed of magnetic &#947;-Fe<sub>2</sub>O<sub>3</sub> nanoparticles and nanographene oxide (NGO). The magnetic component, obtained by anneal...
  • Article English OPEN
    Tabitha Galindo; Jose Reyna; Andy Weyer;
    (2018)
    Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP...
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