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13,023 Projects, page 1 of 1,303

  • 2015
  • 2017

  • Funder: NIH Project Code: 1R21AI119974-01
    Funder Contribution: 230,625 USD
  • Open Access mandate for Publications
    Funder: EC Project Code: 657025
    Overall Budget: 128,994 EURFunder Contribution: 128,994 EUR
    Partners: IMI BAS

    The project contextually sets up a novel framework to study the spectral-theoretical properties of classes of non-selfadjoint (NSA) operators related to Markov processes (MP) via their intertwining to a continuous path selfadjoint (SA) MP. Conceptually, this means that the jumps of each class of NSA MP can be considered a perturbation of one SA MP realized by an intertwining kernel. This approach can have far-reaching consequences for understanding classes of MP as the reduction to SA MP leads to well-studied objects whereas the spectral theory of NSA operators is far from understood. The price of that is the non-invertability of the intertwining kernels. This framework is explored and crystallized by a challenging, detailed spectral-theoretical study of an enormous class of NSA operators directly arising from the key phenomenon of self-similarity and in duality from branching. This is achieved by a synergy of research fields complementing each other to obtain the spectral properties of those operators culminating in the derivation of spectral expansions of the generated semigroups. As a result of this synergy, a number of tools and techniques with impact, including applications to fields beyond the scope of the project, are derived. A particular development in the area of recurrent equations and special functions will be unexpectedly exploited to the effect of a comprehensive theoretical and applied study, including numerical schemes, of key quantities in financial and insurance mathematics such as Asian options and perpetuities. A training-through-research in line with the fellow’s affiliation to the host institution and the proposed secondment will critically contribute to the optimal completion of the proposal in terms of time, scope and quality.

  • Funder: UKRI Project Code: 509267
    Funder Contribution: 63,300 GBP
    Partners: University of Wolverhampton

    To improve the transfer of information between quotation and model, enabling customer to visualise the product in 3D as they build up the quote using library developed models, reducing the process time from quote to order acceptance to delivery.

  • Funder: NIH Project Code: 1R21AI121689-01
    Funder Contribution: 234,034 USD
  • Funder: UKRI Project Code: MR/M002888/1
    Funder Contribution: 93,647 GBP

    The Public Health Foundation of India, the London School of Hygiene & Tropical Medicine and the National Health Systems Resource Centre (NHSRC) of the Ministry of Health & Family Welfare, Government of India will come together to explore how local participatory governance (LPG) reforms influence equitable access to health services. LPG of social sectors (such as health or education) entails decentralised planning and oversight of services, undertaken through participatory and deliberative processes involving local communities and stakeholders. The salutary impact of LPG on health access is widely acknowledged, however the actual pathways of such change are not well researched, and the role of context in influencing these pathways also remains poorly understood. This research aims to address these gaps in the knowledge, using the case study of Panchayati Raj Institution (PRI) reforms in Kerala state, India. In India, LPG is synonymous with PRIs - locally elected bodies operating at village, sub-district and district levels with financial and administrative powers over social services including health care. Kerala is an example of extensively implemented PRI reform, and hence offers a best-practices scenario for clear identification of contexts and pathways of influence. Our conceptual model is informed by global evidence suggesting that LPG reforms have influences on multiple governance arenas, including politics, civil society and public administration. Resultant improvements in political accountability, community empowerment and health system responsiveness can act synergistically to enhance equitable access to health care. These broad putative pathways of influence provide a basic framework for more detailed empirical investigation. Specific objectives: 1. Explicate the pathways through which institutions of local participatory governance (LPG) influence access to health care for the poor and vulnerable, through a case study of the Panchayati Raj Institution (PRI) local governance system in Kerala state, India 2. Understand the policy context of implementation of Kerala's PRI reforms for LPG in health care 3. Explore and strengthen the application of innovative Health Policy & Systems Research (HPSR) approaches in exploring LPG and its influence on equitable access to health care across different low & middle-income country (LMIC) settings The study will engage innovative HPSR approaches drawing on the social sciences, including realist enquiry and actor-focused approaches to policy implementation. Qualitative methodology, including in-depth interviews and focus groups conducted in four districts, will help access the lived experiences of involved policy actors (representing PRI committees, service users, civil society and health systems). Data will be analyzed using the "framework" approach for policy research developed by the UK National Centre for Social Research, combining pre-determined and emerging themes. Data collection strategies will be revised iteratively as the study progresses, an approach that will be fundamental to innovating with HPSR methods. Towards the end of the study, we will convene a workshop to share preliminary findings and develop a larger proposal. The larger proposal will examine the role of LPG mechanisms in facilitating greater access to services in several Indian states and countries in sub-Saharan Africa. The study emerges from needs expressed by policymakers in India, for deeper understanding of how to support LPG for health, and will fulfill that need. The integral role of NHSRC in the study will facilitate policy uptake of findings. The findings will support accountability and greater citizen participation in decisions that affect them - and ultimately greater access to healthcare for marginalized people, across LMIC settings. The study will also contribute to conceptual innovation and methods in the field of HPSR, and help strengthen UK-India research collaborations.

  • Open Access mandate for Publications
    Funder: EC Project Code: 691371
    Overall Budget: 2,753,850 EURFunder Contribution: 1,991,940 EUR

    In the frame of the project we will finalise the development and the market placement of our new electric drive inside the wheel that will represent a technological break-through and will address mobility challenges in EU and global urban transportation. The GEM in-wheel product represents unique solution on the targeted market with integrated motor controller and electric motor inside the wheel. Using patent pending modular technology, the product significantly improves the state-of-the-art characteristics of in-wheel products on the global market by increasing efficiency (above 92%), torque (higher up to 25%) and lowering weight (up to 25% to competitive products). In addition the modular technology also allows a very easy adaption to various customer needs allowing to develop a cost-efficient complete product range. Main competitve advantages of our solution are: smart and simple design, low voltage, modular technology, regenerative braking, easy scalability, high reliability, excellent motor performance and excellent price/performance ratio. To achieve project goals a trans-disciplinary consortium with competent partners on their field is established. The project leader Gem motors as developer of the motor technology, joined forces with experienced partners that complement their roles: Domel as long-term and well established company in the field of electric motor production, Fraunhofer IAO as the first class research institute in the e-mobility field of production and business management, Luznar as small competent producer specialized in-wheel power electronics and City motion-Eccity as an emerging key producer of electric scooters in EU. Other third parties for motor parts production, research, structural analysis and five key customers are completing the network thus forming a complete and competent consortium to successfully accomplish the project’s objectives. Project topics are directly in-line with the Work Programme FTI.

  • Open Access mandate for Publications
    Funder: EC Project Code: 660753
    Overall Budget: 160,800 EURFunder Contribution: 160,800 EUR

    Although many thousands of transient protein-protein interactions (PPIs) are known, there is a disturbing paucity of high-resolution structures of the resulting complexes and the difficulties involved in experimentally determining these atomic structures remain essentially unaddressed. The Steyaert lab has shown that cross-linking transiently interacting proteins, followed by immunization of llama’s with this cross-linked antigen, causes the maturation of single domain antibodies called Nanobodies (Nbs). The Nbs bind composite conformational epitopes unique to the transient complex. Highly efficient selection methods can discriminate Nbs that exclusively bind the transient (non-cross-linked) complex from binders that bind to the dissociated monomers. Such Nbs will be instrumental to purify and solve the structures of PPIs that have been resistant to investigation by X-ray, NMR, SAXS or EM and for the functional analysis of these complexes within a living cell. This ground-breaking technology will be validated with well-chosen case studies covering key PPIs of the GPCR transmembrane signaling pathway including parts of the arrestin interactome. During this project the fellow will establish a unique research niche by systematically applying her arsenal of learnt techniques to develop the next generation antibody‐enabled methods for the structural investigation of the GPCR-arrestin targets. The ultimate goal of NESIAC is to determine the atomic structures of the most relevant transient associations of these signaling proteins. This will open up a new platform for realising the structural basis of the elusive GPCR regulation by arrestins.

  • Funder: NIH Project Code: 7R03DA037405-02
    Funder Contribution: 95,900 USD
  • Funder: NSF Project Code: 1539920
    Partners: TCNJ
  • Funder: NSF Project Code: 1517367
    Partners: TKU
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