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1,628 Projects

  • OA Publications Mandate: Yes
  • 2020
  • 2022

10
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  • Funder: EC Project Code: 841957
    Overall Budget: 171,473 EURFunder Contribution: 171,473 EUR

    The second most important cause of death and morbidity in Europe is cancer and B-cell acute lymphoblastic leukaemia (B-ALL) is the most common paediatric cancer and cause of cancer-related death before 20 years. In up to 7% of cases, the disease is caused by rearrangements of the genetic regulator DUX4 to the IGH locus, giving rise to the DUX4-IGH fusion. While ectopic expression of DUX4 induces cell death, DUX4-IGH drives transformation. Even though the two proteins share the same DNA binding domain (dbd), DUX4 and DUX4-IGH drive the transcription of non-overlapping target genes. Through proteomics, my lab identified a specific DUX4-IGH inhibitor, which directly binds to DUX4-IGH dbd blocking the activation of target genes. Based on this evidence, the goal of IDEAL is to test the antileukemic activity of the inhibitor in pre-clinical settings. Using cellular models, I will test the ability of the inhibitor to block transformation driven by DUX4-IGH. I expect to see a significant inhibition of DUX4-IGH driven transformation in the presence of its inhibitor, associated with reduced proliferation, clonogenic and self-renewal potential. To test the efficacy of DUX4-IGH inhibition in leukemia development, I will employ animal models (murine bone marrow transplantation assays and patient derived xenografts of DUX4-IGH B-ALL) and assess disease latency in the presence or absence of the inhibitor. I predict that the inhibitor will block or significantly delay DUX4-IGH B-ALL. Pre-clinical validation of the DUX4-IGH inhibitor will help defining effective therapeutic strategies for DUX4-IGH B-ALL patients, improving clinical outcome and lowering treatment toxicity, thus overall promoting Europe's healthcare. Through IDEAL I will expand my expertise in leukaemia research and I will acquire project management and leadership abilities that will foster my personal and professional development as an independent scientist.

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  • Funder: EC Project Code: 888258
    Overall Budget: 137,605 EURFunder Contribution: 137,605 EUR

    I will carry out a research program to understand how cosmological structures evolve and how the corresponding observables are modified in an inhomogeneous universe. This project will place the field of inhomogeneous cosmologies into the era of precision cosmology. Indeed, it is very difficult to obtain the evolution of structures when the background is inhomogeneous and it has not been possible to fully constrain inhomogeneous cosmologies because of this lack of understanding. As I will argue, the most promising approach is via Numerical Cosmology. This justifies why this fellowship will be carried out at the Astronomical Observatory of Trieste under the supervision of Stefano Borgani, one of the world experts in Numerical Cosmology. The scientific motivation behind this effort is that cosmology is undergoing a crisis, facing, at the same time, unexplained components (dark matter and dark energy) and a >4sigma tension between local and global determinations of the Hubble constant. It is then imperative to test basic assumptions in cosmology, such as large-scale homogeneity and isotropy. These are indeed among the objectives of many major space- and earth-based international collaborations (Euclid, LSST, SKA), which will produce detailed maps of a good fraction of the observable universe. Only after carrying out these tests can one hope to discover the nature of dark matter and dark energy.

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  • Funder: EC Project Code: 893181
    Overall Budget: 162,806 EURFunder Contribution: 162,806 EUR

    The question of how an isolated quantum mechanical system thermalizes is not only significant in condensed matter physics, but it also invokes the intriguing problem of the apparent loss of information in a complex system as it thermalizes. A curious case is when a complex system fails to thermalize altogether -- a phenomenon known as many-body localization (MBL). Here, we propose to use interacting ultracold fermions in a lattice to experimentally study the distinctive properties of MBL using a novel set of observables. Among the questions in MBL debated intensely today are those concerning the existence of a many-body mobility edge, many-body intermediate phase and localization in higher dimensional lattice systems. Moreover, the striking relation between non-ergodicity and Hilbert space fragmentation is also not fully understood. In this view, our research objectives include: [1.] Stark many-body localization and Hilbert space fragmentation. We plan to study MBL in a tilted lattice, i.e., a Stark Hamiltonian and study non-ergodicity resulting from Hilbert space fragmentation. [2.] Bipartite fluctuations in an MBL system of >100 lattice sites: We propose to characterize the localization properties using bipartite fluctuations which is a proxy for the Entanglement entropy of a 1D lattice. [3.] Approximate theories for fermionic MBL systems: Due to the exponential Hilbert space dimension of an interacting many-body system, studying their properties numerically is also exponentially hard. We plan to use a quantum simulator with >100 lattice sites develop efficient approximate theories to describe these systems. The aforementioned projects are easily accessible to the current experimental capability and they will enhance our general understanding of MBL physics. Moreover, they also include a step towards developing ultracold atoms in a lattice into a quantum simulator, capable of solving hard problems.

    more_vert
  • Funder: EC Project Code: 894411
    Overall Budget: 224,934 EURFunder Contribution: 224,934 EUR

    The Colombian peace process signed in 2016 has shown that even when peace agreements include comprehensive measures to tackle structural inequalities seen as the root causes of the conflict, they may still be rejected by the very societal groups meant to benefit from such transformative provisions. IPAP addresses this dilemma by exploring how peacebuilding institutions can implement a peace agreement that is contested and work to include groups who have engaged in antagonistic actions against the peace accord. The research counters a tendency in the literature to treat resistance against peacebuilding as deviance or abnormality or as a mere manifestation of political and economic elites’ fear of losing power, by including the intersectional politics which explains these groups’ undermining or rejection of the peace process. The objectives of IPAP are: 1) to identify the fabric of antagonistic forces to peace and map their relations with political actors; 2) to examine the intersectional systems of power differentials through which antagonistic subject positions emerge and analyse how they transform into agonistic, i.e. constructively conflictive, relations with the work of peacebuilding institutions; 3) to explore possibilities for peacebuilding institutions to gain sustained legitimacy among the local population; 4) to identify ways in which peace institutions might engage with difference and create spaces where adversaries can engage in agonistic dialogue. To achieve these objectives, IPAP uses a feminist intersectional lens to peacebuilding, and an ethnographic fieldwork approach, to empirically study Colombia as a rich case of antagonism to peacebuilding. The innovative approach of IPAP consists in advancing the notion of antagonistic subject positions to peace to identify the intersecting relations of power through which groups of population who resist peacebuilding processes are organized and how they can commit to agonistic dialogue.

    more_vert
  • Funder: EC Project Code: 840829
    Overall Budget: 224,934 EURFunder Contribution: 224,934 EUR

    The goal of this project is to exploit ancient Northern European landraces and improve the ability of the important cereal, barley, to acquire and utilize nutrients from the soil more efficiently. Climate change pressures and degradation of arable lands are expected to increase the need to produce feed and food even in unfavorable environments, such as marginal soils with inherent nutrient limitations. Thus, it will be a major breeding focus to select traits associated with enhanced crop robustness in order to secure the future demand for plant products. In this context, recent work has demonstrated a superior capacity of Northern European barley landraces, adapted to marginal soils, to acquire and allocate essential micronutrients. This project aims to advance our knowledge of adaptive traits conferring nutrient use efficiency. This will be achieved by bridging disciplines of plant genetics and plant nutrition, not only by unravelling functions of individual genes, but also by capturing the compensatory adjustments at the transcriptome and molecular physiology levels, preserved in landraces but seemingly lost from modern elite cultivars. The overall scientific objective is to identify the genetic control of nutrient stress tolerance, and specifically to: (i) use exome capture sequencing to identify candidate genes involved in nutrient deficiency tolerance; (ii) study the transcriptional responses of these genes under nutrient stress and their dynamics with time after stress recovery; (iii) describe in detail the physiological responses contributing to improved nutrient stress tolerance of major cereal crops. The proposed project will deliver quantitative information and a predictive understanding of nutrient stress tolerance and will provide new breeding material. The findings will act as an exemplar for other major cereals to expand cultivation and stabilize yields in marginal previously unproductive land.

    more_vert
  • Funder: EC Project Code: 954604
    Overall Budget: 2,580,000 EURFunder Contribution: 1,806,000 EUR

    The BIONIC FEEDBACK SYSTEM. The Austrian company SAPHENUS Medical Technology, founded in 2016, has set itself the goal of improving the quality of people who lack the feeling in the legs, whether through polyneuropathy or through amputation. 1,5 million amputees and 7,5 million people with polyneuropathy and serious sensory problems are affected all over Europe. For these two target groups SAPHENUS has the breakthrough solution using the bionic principle. With the Bionic Feedback System (BFS) the affected persons get back the feeling of the lost or damaged foot, they feel authentic again, and the brain is provided with sensory information again. SURALIS and CUTANEUS, the two BFS-products of SAPHENUS are patented high-tec add-on devices that consist of (i) a sensor sole and (ii) a transmission part which is applied on the stump or leg. SURALIS and CUTANEUS represent a new medical product category supporting cost-efficient, affordable, optimised care for amputees and diabetics. SAPHENUS has a strong network in medical research as well as in health insurances and in distribution partners. The SME-Instrument phase 1 business plan shall now be further implemented. The phase 2 workplan foresees a duration of 24 months and requests 1,8 mio of EC funding.

    more_vert
  • Funder: EC Project Code: 101016065
    Overall Budget: 7,911,320 EURFunder Contribution: 7,203,360 EUR

    COVID-X will bridge the collaboration divide between eHealth solution providers -with emphasis on lean startups and small and medium-sized enterprises (SMEs)-, and the healthcare professional system to fight COVID-19. The purpose is to boost an end-to-end agile validation programme of cutting-edge technology in three real-world clinical scenarios, located in hotspots of the pandemic: Italy, Spain and Sweden. The project will fast-track value streams between the two poles under consideration: 1) attract, invest and empower a community of European eHealth SMEs –the beneficiaries of an acceleration program, selected by open calls- that will provide market-ready fast, cost-effective and easily deployable sampling, screening, diagnostic and prognostic systems and/or data-driven services and tools, already certified with -or close to receive- the CE marking (type 1 of the call); 2) actively involve some of the most relevant hospitals of Europe that have the resources, critical mass and ambition to scale-up their capabilities in the COVID-19 response; thanks to the support of an innovative data sandbox, released as an in-house asset of COVID-X, to facilitate access easily, uniformly and securely to various health data sources, and providing data services including Artificial Intelligence (AI)-based decision support systems, data security, visual analytics and intuitive dashboards capabilities. The project will invest dedicated efforts to enforce data privacy and security, ethical compliance and user acceptance. Besides a solid consortium to access world class startups/SMEs, deliver highly valuable technological & business services, provide an innovative data Sandbox with AI capabilities for COVID related services and access 3 piloting sites, COVID-X targets to attract +155 applications and select 31 to undertake through the COVID-X Programme, investing a total of €4.0mil in high impact solution providers.

    visibility134
    visibilityviews134
    downloaddownloads341
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    more_vert
  • Funder: EC Project Code: 895158
    Overall Budget: 224,934 EURFunder Contribution: 224,934 EUR

    Forests form a major terrestrial carbon sink, but its size is subject to large uncertainties. Recent advances in the quantification of the sink have highlighted the need for accounting for the effects of forest management and tree mortality. However, management and mortality have been considered in isolation from each other, even though management practises are known have large effects on tree mortality. So far, the lack of suitable management data has hindered the realistic consideration of management effects on forest dynamics in global vegetation models. ForMMI aims to fill these gaps by (1) developing novel observation-based methodology to quantify forest management regimes from single-measurement national forest inventory data, (2) creating statistical models that allow calculation of mortality rates based on management type and intensity and (3) integrating these models into a dynamic global vegetation model LPJ-GUESS and use it to quantify the implications to carbon cycle. The methodological development will enable obtaining of observations-based management information over large areas, thus greatly improving the current use of national-level statistics and assumptions based on management guidelines. This will greatly benefit the future efforts of linking management to forest dynamics in large-scale models. The results will provide a first large-scale and consistent assessment of management impacts on natural mortality of trees and quantify the implications for carbon cycle. This will create an important basis in accounting for management-mortality interactions in global vegetation models, on which further research will be able to build on. The project will provide Dr Suvanto with the skills and expertise needed to establish a leading international role in forest management-mortality interactions, a research direction with increasing importance as current efforts on including management effects and mortality processes to large-scale models move forward.

    more_vert
  • Funder: EC Project Code: 101003405
    Overall Budget: 144,981 EURFunder Contribution: 144,981 EUR

    The most common ionizing radiation detectors using inorganic solid scintillators do not currently enable the technological progress in the fields of high-energy particles detection and medical diagnosis (such as in time-of-flight PET tomography), where high light yield and fast timing capabilities are needed. Nanoparticles can be exploited as scintillators to overcome these limits due to the possibility to control and modify their structural and luminescence properties. Moreover, nanoparticles can be embedded in polymers for the fabrication of nanocomposites with high optical transparency. The main goal of the project is to develop advanced hafnium oxide nanocomposite scintillators with time response in nanoseconds, while exploiting the hafnia quality to efficiently stop the ionizing radiation. In order to reach the project goal, the radioluminescence properties of inorganic hafnia nanoparticles will be optimized by defects engineering and doping strategies. The hafnia surfaces will be decorated with highly fluorescent organic dyes and the radioluminescence of nanoparticles will sensitize the dye emission. These hybrid nanoscintillators will be embedded in a polymer matrix in order to fabricate low cost, flexible and scalable nanocomposite scintillators with optimized luminescence efficiency and fast time response. The project is at the forefront of the progress in high-energy physics experiments to minimize the photons losses at high count rates, and meets the urgent demands of medical imaging techniques to gain high quality images. The results of the proposed research will represent a fundamental step forward towards significant advances in technologies for ionizing radiation detection as well as reinforce the position of the European scintillation community worldwide.

    more_vert
  • Funder: EC Project Code: 843405
    Overall Budget: 174,806 EURFunder Contribution: 174,806 EUR

    During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

    visibility205
    visibilityviews205
    downloaddownloads127
    Powered by Usage counts
    more_vert
Advanced search in
Projects
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arrow_drop_down
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1,628 Projects
  • Funder: EC Project Code: 841957
    Overall Budget: 171,473 EURFunder Contribution: 171,473 EUR

    The second most important cause of death and morbidity in Europe is cancer and B-cell acute lymphoblastic leukaemia (B-ALL) is the most common paediatric cancer and cause of cancer-related death before 20 years. In up to 7% of cases, the disease is caused by rearrangements of the genetic regulator DUX4 to the IGH locus, giving rise to the DUX4-IGH fusion. While ectopic expression of DUX4 induces cell death, DUX4-IGH drives transformation. Even though the two proteins share the same DNA binding domain (dbd), DUX4 and DUX4-IGH drive the transcription of non-overlapping target genes. Through proteomics, my lab identified a specific DUX4-IGH inhibitor, which directly binds to DUX4-IGH dbd blocking the activation of target genes. Based on this evidence, the goal of IDEAL is to test the antileukemic activity of the inhibitor in pre-clinical settings. Using cellular models, I will test the ability of the inhibitor to block transformation driven by DUX4-IGH. I expect to see a significant inhibition of DUX4-IGH driven transformation in the presence of its inhibitor, associated with reduced proliferation, clonogenic and self-renewal potential. To test the efficacy of DUX4-IGH inhibition in leukemia development, I will employ animal models (murine bone marrow transplantation assays and patient derived xenografts of DUX4-IGH B-ALL) and assess disease latency in the presence or absence of the inhibitor. I predict that the inhibitor will block or significantly delay DUX4-IGH B-ALL. Pre-clinical validation of the DUX4-IGH inhibitor will help defining effective therapeutic strategies for DUX4-IGH B-ALL patients, improving clinical outcome and lowering treatment toxicity, thus overall promoting Europe's healthcare. Through IDEAL I will expand my expertise in leukaemia research and I will acquire project management and leadership abilities that will foster my personal and professional development as an independent scientist.

    more_vert
  • Funder: EC Project Code: 888258
    Overall Budget: 137,605 EURFunder Contribution: 137,605 EUR

    I will carry out a research program to understand how cosmological structures evolve and how the corresponding observables are modified in an inhomogeneous universe. This project will place the field of inhomogeneous cosmologies into the era of precision cosmology. Indeed, it is very difficult to obtain the evolution of structures when the background is inhomogeneous and it has not been possible to fully constrain inhomogeneous cosmologies because of this lack of understanding. As I will argue, the most promising approach is via Numerical Cosmology. This justifies why this fellowship will be carried out at the Astronomical Observatory of Trieste under the supervision of Stefano Borgani, one of the world experts in Numerical Cosmology. The scientific motivation behind this effort is that cosmology is undergoing a crisis, facing, at the same time, unexplained components (dark matter and dark energy) and a >4sigma tension between local and global determinations of the Hubble constant. It is then imperative to test basic assumptions in cosmology, such as large-scale homogeneity and isotropy. These are indeed among the objectives of many major space- and earth-based international collaborations (Euclid, LSST, SKA), which will produce detailed maps of a good fraction of the observable universe. Only after carrying out these tests can one hope to discover the nature of dark matter and dark energy.

    visibility355
    visibilityviews355
    downloaddownloads460
    Powered by Usage counts
    more_vert
  • Funder: EC Project Code: 893181
    Overall Budget: 162,806 EURFunder Contribution: 162,806 EUR

    The question of how an isolated quantum mechanical system thermalizes is not only significant in condensed matter physics, but it also invokes the intriguing problem of the apparent loss of information in a complex system as it thermalizes. A curious case is when a complex system fails to thermalize altogether -- a phenomenon known as many-body localization (MBL). Here, we propose to use interacting ultracold fermions in a lattice to experimentally study the distinctive properties of MBL using a novel set of observables. Among the questions in MBL debated intensely today are those concerning the existence of a many-body mobility edge, many-body intermediate phase and localization in higher dimensional lattice systems. Moreover, the striking relation between non-ergodicity and Hilbert space fragmentation is also not fully understood. In this view, our research objectives include: [1.] Stark many-body localization and Hilbert space fragmentation. We plan to study MBL in a tilted lattice, i.e., a Stark Hamiltonian and study non-ergodicity resulting from Hilbert space fragmentation. [2.] Bipartite fluctuations in an MBL system of >100 lattice sites: We propose to characterize the localization properties using bipartite fluctuations which is a proxy for the Entanglement entropy of a 1D lattice. [3.] Approximate theories for fermionic MBL systems: Due to the exponential Hilbert space dimension of an interacting many-body system, studying their properties numerically is also exponentially hard. We plan to use a quantum simulator with >100 lattice sites develop efficient approximate theories to describe these systems. The aforementioned projects are easily accessible to the current experimental capability and they will enhance our general understanding of MBL physics. Moreover, they also include a step towards developing ultracold atoms in a lattice into a quantum simulator, capable of solving hard problems.

    more_vert
  • Funder: EC Project Code: 894411
    Overall Budget: 224,934 EURFunder Contribution: 224,934 EUR

    The Colombian peace process signed in 2016 has shown that even when peace agreements include comprehensive measures to tackle structural inequalities seen as the root causes of the conflict, they may still be rejected by the very societal groups meant to benefit from such transformative provisions. IPAP addresses this dilemma by exploring how peacebuilding institutions can implement a peace agreement that is contested and work to include groups who have engaged in antagonistic actions against the peace accord. The research counters a tendency in the literature to treat resistance against peacebuilding as deviance or abnormality or as a mere manifestation of political and economic elites’ fear of losing power, by including the intersectional politics which explains these groups’ undermining or rejection of the peace process. The objectives of IPAP are: 1) to identify the fabric of antagonistic forces to peace and map their relations with political actors; 2) to examine the intersectional systems of power differentials through which antagonistic subject positions emerge and analyse how they transform into agonistic, i.e. constructively conflictive, relations with the work of peacebuilding institutions; 3) to explore possibilities for peacebuilding institutions to gain sustained legitimacy among the local population; 4) to identify ways in which peace institutions might engage with difference and create spaces where adversaries can engage in agonistic dialogue. To achieve these objectives, IPAP uses a feminist intersectional lens to peacebuilding, and an ethnographic fieldwork approach, to empirically study Colombia as a rich case of antagonism to peacebuilding. The innovative approach of IPAP consists in advancing the notion of antagonistic subject positions to peace to identify the intersecting relations of power through which groups of population who resist peacebuilding processes are organized and how they can commit to agonistic dialogue.

    more_vert
  • Funder: EC Project Code: 840829
    Overall Budget: 224,934 EURFunder Contribution: 224,934 EUR

    The goal of this project is to exploit ancient Northern European landraces and improve the ability of the important cereal, barley, to acquire and utilize nutrients from the soil more efficiently. Climate change pressures and degradation of arable lands are expected to increase the need to produce feed and food even in unfavorable environments, such as marginal soils with inherent nutrient limitations. Thus, it will be a major breeding focus to select traits associated with enhanced crop robustness in order to secure the future demand for plant products. In this context, recent work has demonstrated a superior capacity of Northern European barley landraces, adapted to marginal soils, to acquire and allocate essential micronutrients. This project aims to advance our knowledge of adaptive traits conferring nutrient use efficiency. This will be achieved by bridging disciplines of plant genetics and plant nutrition, not only by unravelling functions of individual genes, but also by capturing the compensatory adjustments at the transcriptome and molecular physiology levels, preserved in landraces but seemingly lost from modern elite cultivars. The overall scientific objective is to identify the genetic control of nutrient stress tolerance, and specifically to: (i) use exome capture sequencing to identify candidate genes involved in nutrient deficiency tolerance; (ii) study the transcriptional responses of these genes under nutrient stress and their dynamics with time after stress recovery; (iii) describe in detail the physiological responses contributing to improved nutrient stress tolerance of major cereal crops. The proposed project will deliver quantitative information and a predictive understanding of nutrient stress tolerance and will provide new breeding material. The findings will act as an exemplar for other major cereals to expand cultivation and stabilize yields in marginal previously unproductive land.

    more_vert
  • Funder: EC Project Code: 954604
    Overall Budget: 2,580,000 EURFunder Contribution: 1,806,000 EUR

    The BIONIC FEEDBACK SYSTEM. The Austrian company SAPHENUS Medical Technology, founded in 2016, has set itself the goal of improving the quality of people who lack the feeling in the legs, whether through polyneuropathy or through amputation. 1,5 million amputees and 7,5 million people with polyneuropathy and serious sensory problems are affected all over Europe. For these two target groups SAPHENUS has the breakthrough solution using the bionic principle. With the Bionic Feedback System (BFS) the affected persons get back the feeling of the lost or damaged foot, they feel authentic again, and the brain is provided with sensory information again. SURALIS and CUTANEUS, the two BFS-products of SAPHENUS are patented high-tec add-on devices that consist of (i) a sensor sole and (ii) a transmission part which is applied on the stump or leg. SURALIS and CUTANEUS represent a new medical product category supporting cost-efficient, affordable, optimised care for amputees and diabetics. SAPHENUS has a strong network in medical research as well as in health insurances and in distribution partners. The SME-Instrument phase 1 business plan shall now be further implemented. The phase 2 workplan foresees a duration of 24 months and requests 1,8 mio of EC funding.

    more_vert
  • Funder: EC Project Code: 101016065
    Overall Budget: 7,911,320 EURFunder Contribution: 7,203,360 EUR

    COVID-X will bridge the collaboration divide between eHealth solution providers -with emphasis on lean startups and small and medium-sized enterprises (SMEs)-, and the healthcare professional system to fight COVID-19. The purpose is to boost an end-to-end agile validation programme of cutting-edge technology in three real-world clinical scenarios, located in hotspots of the pandemic: Italy, Spain and Sweden. The project will fast-track value streams between the two poles under consideration: 1) attract, invest and empower a community of European eHealth SMEs –the beneficiaries of an acceleration program, selected by open calls- that will provide market-ready fast, cost-effective and easily deployable sampling, screening, diagnostic and prognostic systems and/or data-driven services and tools, already certified with -or close to receive- the CE marking (type 1 of the call); 2) actively involve some of the most relevant hospitals of Europe that have the resources, critical mass and ambition to scale-up their capabilities in the COVID-19 response; thanks to the support of an innovative data sandbox, released as an in-house asset of COVID-X, to facilitate access easily, uniformly and securely to various health data sources, and providing data services including Artificial Intelligence (AI)-based decision support systems, data security, visual analytics and intuitive dashboards capabilities. The project will invest dedicated efforts to enforce data privacy and security, ethical compliance and user acceptance. Besides a solid consortium to access world class startups/SMEs, deliver highly valuable technological & business services, provide an innovative data Sandbox with AI capabilities for COVID related services and access 3 piloting sites, COVID-X targets to attract +155 applications and select 31 to undertake through the COVID-X Programme, investing a total of €4.0mil in high impact solution providers.

    visibility134
    visibilityviews134
    downloaddownloads341
    Powered by Usage counts
    more_vert
  • Funder: EC Project Code: 895158
    Overall Budget: 224,934 EURFunder Contribution: 224,934 EUR

    Forests form a major terrestrial carbon sink, but its size is subject to large uncertainties. Recent advances in the quantification of the sink have highlighted the need for accounting for the effects of forest management and tree mortality. However, management and mortality have been considered in isolation from each other, even though management practises are known have large effects on tree mortality. So far, the lack of suitable management data has hindered the realistic consideration of management effects on forest dynamics in global vegetation models. ForMMI aims to fill these gaps by (1) developing novel observation-based methodology to quantify forest management regimes from single-measurement national forest inventory data, (2) creating statistical models that allow calculation of mortality rates based on management type and intensity and (3) integrating these models into a dynamic global vegetation model LPJ-GUESS and use it to quantify the implications to carbon cycle. The methodological development will enable obtaining of observations-based management information over large areas, thus greatly improving the current use of national-level statistics and assumptions based on management guidelines. This will greatly benefit the future efforts of linking management to forest dynamics in large-scale models. The results will provide a first large-scale and consistent assessment of management impacts on natural mortality of trees and quantify the implications for carbon cycle. This will create an important basis in accounting for management-mortality interactions in global vegetation models, on which further research will be able to build on. The project will provide Dr Suvanto with the skills and expertise needed to establish a leading international role in forest management-mortality interactions, a research direction with increasing importance as current efforts on including management effects and mortality processes to large-scale models move forward.

    more_vert
  • Funder: EC Project Code: 101003405
    Overall Budget: 144,981 EURFunder Contribution: 144,981 EUR

    The most common ionizing radiation detectors using inorganic solid scintillators do not currently enable the technological progress in the fields of high-energy particles detection and medical diagnosis (such as in time-of-flight PET tomography), where high light yield and fast timing capabilities are needed. Nanoparticles can be exploited as scintillators to overcome these limits due to the possibility to control and modify their structural and luminescence properties. Moreover, nanoparticles can be embedded in polymers for the fabrication of nanocomposites with high optical transparency. The main goal of the project is to develop advanced hafnium oxide nanocomposite scintillators with time response in nanoseconds, while exploiting the hafnia quality to efficiently stop the ionizing radiation. In order to reach the project goal, the radioluminescence properties of inorganic hafnia nanoparticles will be optimized by defects engineering and doping strategies. The hafnia surfaces will be decorated with highly fluorescent organic dyes and the radioluminescence of nanoparticles will sensitize the dye emission. These hybrid nanoscintillators will be embedded in a polymer matrix in order to fabricate low cost, flexible and scalable nanocomposite scintillators with optimized luminescence efficiency and fast time response. The project is at the forefront of the progress in high-energy physics experiments to minimize the photons losses at high count rates, and meets the urgent demands of medical imaging techniques to gain high quality images. The results of the proposed research will represent a fundamental step forward towards significant advances in technologies for ionizing radiation detection as well as reinforce the position of the European scintillation community worldwide.

    more_vert
  • Funder: EC Project Code: 843405
    Overall Budget: 174,806 EURFunder Contribution: 174,806 EUR

    During 1990s, there was an epidemic of diphtheria in Russia and other countries of the former USSR affecting about 200, 000 people with 5000 deaths. Although diphtheria incidence in Russia has declined substantially, recent reports from several EU countries indicate circulation of toxigenic C. diphtheriae among migrants from Asia and Africa as well as children’s deaths among indigenous population. Toxigenic C. diphtheriae poses a serious risk for unvaccinated persons and persons with low level of immunological protection, the number of which in recent times in Europe has increased. The International system of quality control revealed poor state of laboratory diagnosis of diphtheria in EU countries, which means we are not prepared for the possible outbreaks. This is mostly due to the absence of simple, standard and reliable diagnostic methods. The leading element in the diphtheria laboratory diagnostic approach is a detection of the bacterial toxin. In this regard, it is proposed to develop non-apparatus immunochromatographic strip (ICS) test for diphtheria toxin (DT) indication. In addition a liquid selective medium for the clinical sample cultivation will be designed. A combination of the ICS test and the medium will represent a novel assay for early diphtheria diagnosis. The reagent kit will be commercially produced. The availability of simple, reliable and affordable ICS assay for DT detection will increase the accuracy of diphtheria diagnosis in EU and other countries and reduce the duration of its execution up to 6 hours (instead of 5-7 days as recommended by the WHO manual). The efficient early diphtheria diagnosis will enable timely initiation of anti-diphtheritic treatment that will save lives, prevent the development of complications (heart failure, paralysis), as well as stop the spread of the disease through initiation of preventive measures (vaccination and antibiotic prophylaxis) in case of disease outbreaks.

    visibility205
    visibilityviews205
    downloaddownloads127
    Powered by Usage counts
    more_vert