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89 projects, page 1 of 9
  • project . 2021 - 2026
    Funder: WT Project Code: 220799
    Funder Contribution: 1,104,080 GBP
    Open Access mandate for Publications
    Partners: University of Bristol, UNIVERSITY OF BRISTOL

    The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress excitatory and inhibitory synaptic transmission. This is critically important for a wide range of brain functions including appetite, pain, and cognition. Moreover, ECS dysfunction is imp...

  • project . 2021 - 2026
    Funder: WT Project Code: 221807
    Funder Contribution: 1,490,730 GBP
    Open Access mandate for Publications
    Partners: King's College London

    The overarching goal of this proposal is to elucidate the functional diversity of the pancreatic mesenchymal lineage. In embryonic tissues, epithelial progenitors receive paracrine signals from the surrounding mesenchymal niche, which can modulate their ability to proli...

  • project . 2021 - 2026
    Funder: WT Project Code: 221786
    Funder Contribution: 1,492,840 GBP
    Open Access mandate for Publications
    Partners: University of Glasgow

    Cell migration is essential to processes throughout biology, especially embryonic development and immune function. Migration must be steered to be physiologically effective. Steering cues are not well understood; we know a lot about how cells interpret them, but relativ...

  • project . 2021 - 2026
    Funder: WT Project Code: 221776
    Funder Contribution: 1,271,160 GBP
    Open Access mandate for Publications
    Partners: John Innes Centre

    ATP and GTP switches are extensively used to control conformations and functions of proteins in a wide range of biological processes. However, CTP switches have rarely been found in biology. Recent work from our laboratory and others has shown that ParB is a founding me...

  • project . 2021 - 2026
    Funder: WT Project Code: 220737
    Funder Contribution: 613,982 GBP
    Open Access mandate for Publications
    Partners: University of Glasgow

    Some bacteria species in the mosquito midgut demonstrate anti-Plasmodial effect independent of the mosquito immune system. Understanding this mechanism could help propose bacteria-mediated strategies for targeting and blocking transmission without producing transgenic b...

  • project . 2021 - 2026
    Funder: WT Project Code: 221934
    Funder Contribution: 2,367,250 GBP
    Open Access mandate for Publications
    Partners: University College London

    Cognitive decline represents a significant and debilitating co-morbidity for patients with epilepsy which is poorly understood with an urgent clinical need for diagnostic, preventative and treatment strategies. Large epilepsy MRI datasets confirm progressive cortical at...

  • project . 2021 - 2026
    Funder: WT Project Code: 221725
    Funder Contribution: 2,051,880 GBP
    Open Access mandate for Publications
    Partners: University of Birmingham

    γδ T-cells have been retained in vertebrates for ~500million years, and are of increasing therapeutic interest, but their mode of ligand recognition and immunological niche has remained largely mysterious. Here we build on the emergence of parallel innate-like and adapt...

  • project . 2020 - 2026
    Funder: WT Project Code: FC001986
    Open Access mandate for Publications
    Partners: Francis Crick Institute
  • project . 2020 - 2026
    Funder: WT Project Code: 217267
    Funder Contribution: 2,966,710 GBP
    Open Access mandate for Publications
    Partners: University of Oxford

    Formaldehyde is a ubiquitous reactive aldehyde that is present in our environment. However, a significant amount of formaldehyde is produced in our bodies probably as a consequence of metabolism. We discovered that we possess a two-tier protection mechanism (aldehyde de...

  • project . 2021 - 2026
    Funder: WT Project Code: 221401
    Funder Contribution: 1,560,990 GBP
    Open Access mandate for Publications
    Partners: EMBL-EBI

    Single Cell Expression Atlas (https://www.ebi.ac.uk/gxa/sc) is an open science resource that offers powerful searches for a gene expression data in different cell types, across tissues, species and conditions. Since its launch in May 2018, the Single Cell Expression Atl...

89 projects, page 1 of 9