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410 projects, page 1 of 41
  • project . 2019 - 2024
    Funder: WT Project Code: 217191
    Funder Contribution: 2,740,930 GBP
    Open Access mandate for Publications
    Partners: University Of Cambridge, University of Cambridge

    Viruses depend on cellular machinery to express and replicate their genes. Viral RNA must therefore be delivered or generated in the cytosol. Some viruses also deliver genomic DNA into the nucleus, for integration into the host cell genome. The cell’s principal innate d...

  • project . 2019 - 2021
    Funder: WT Project Code: 213954
    Funder Contribution: 99,905 GBP
    Open Access mandate for Publications
    Partners: Queen Mary University of London, Queen Mary University Of London

    Metagenomic approaches are generating a long list of health and disease states associated with the microbiome (the microbes inhabiting our digestive tract) but without mechanistic understanding. The challenges arise from the enormous complexity of the microbiome, includ...

  • project . 2019 - 2021
    Funder: WT Project Code: 213928
    Funder Contribution: 100,000 GBP
    Open Access mandate for Publications
    Partners: St George's University Of London, St George's University of London

    Anophthalmia, microphthalmia and coloboma arise from defects in eye morphogenesis and are amongst the most severe defects associated with blindness. Some of the genes affected in these conditions have been identified, but in most cases the causes underlying these congen...

  • project . 2019 - 2024
    Funder: WT Project Code: 216458
    Funder Contribution: 728,291 GBP
    Open Access mandate for Publications
    Partners: Africa and Asia Programme - Malawi

    One million people died of HIV in 2017 and an estimated 160 million Africans had active schistosomiasis, a cause of male and female genital lesions likely to increase risk and transmission of HIV. Control of both HIV and schistosomiasis relies mainly on treatment of act...

  • project . 2019 - 2024
    Funder: WT Project Code: 214272
    Funder Contribution: 1,469,610 GBP
    Open Access mandate for Publications
    Partners: University Of Cambridge, University of Cambridge

    Coated vesicles transport molecules from one membrane compartment of the cell (a "donor" compartment) to another ("acceptor") compartment. Adaptors are the components of the coat that select the vesicle cargo. The adaptor protein complexes AP-1 and AP-2 are associated w...

  • project . 2019 - 2019
    Funder: WT Project Code: 219711
    Funder Contribution: 5,000 GBP
    Open Access mandate for Publications
    Partners: Behavioural Insights Team

    This grant is to carry out the scoping phase of a proposal for secondary school science teachers to be supported to engage with research by using lesson plans to support their teaching of a specific unit of physics to Y8 pupils. Lesson plans will have clickable links to...

  • project . 2019 - 2023
    Funder: WT Project Code: 213555
    Funder Contribution: 300,000 GBP
    Open Access mandate for Publications
    Partners: Queen Mary University of London

    The development of antibody-producing plasma cells and memory B cells (MBCs) is essential for immunological memory, yet the transcriptional mechanisms that regulate these different B cell fates are poorly understood. One reason for this is the highly dynamic and heterog...

  • project . 2019 - 2024
    Funder: WT Project Code: 214342
    Funder Contribution: 2,506,070 GBP
    Open Access mandate for Publications
    Partners: University College London

    We recently discovered that aberrant cell death induced by death ligands beyond TNF causes lethal inflammation induced by perturbed linear ubiquitination (linUb). Importantly, cell death induction by death ligands other than TNF requires RIPK1 kinase activity in vivo wh...

  • project . 2019 - 2021
    Funder: WT Project Code: 217058
    Funder Contribution: 199,914 GBP
    Open Access mandate for Publications
    Partners: London School of Hygiene & Tropical Medicine, London School Of Hygiene & Tropical Medicine

    This project aims to address the problem that the sheer number of outbreak events around the world prevents experts involved in outbreak detection and response from analysing and reflecting on the lessons learned from previous outbreaks because they are so busy respondi...

  • project . 2019 - 2020
    Funder: WT Project Code: 219742
    Funder Contribution: 27,020 GBP
    Open Access mandate for Publications
    Partners: Centre for Infectious Disease Research in Zambia

    We aim to contribute to strengthening capacity of ethical and regulatory bodies in governing Human Infection Studies (HIS) and developing an ethical and regulatory framework applicable to Zambia and other low middle income countries (LMICs). Being new to Zambia, there i...

410 projects, page 1 of 41